Gene description for CNOT11
Gene name CCR4-NOT transcription complex, subunit 11
Gene symbol CNOT11
Other names/aliases C2orf29
C40
Species Homo sapiens
 Database cross references - CNOT11
ExoCarta ExoCarta_55571
Vesiclepedia VP_55571
Entrez Gene 55571
HGNC 25217
UniProt Q9UKZ1  
 CNOT11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for CNOT11
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 NAS
    regulation of translation GO:0006417 IEA
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
    CCR4-NOT complex GO:0030014 IBA
    CCR4-NOT complex GO:0030014 IDA
    CCR4-NOT complex GO:0030014 NAS
 Experiment description of studies that identified CNOT11 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CNOT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C9orf78 51759
Affinity Capture-MS Homo sapiens
2 CNOT7 29883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ATG16L1 55054
Affinity Capture-MS Homo sapiens
4 C2CD4B  
Affinity Capture-MS Homo sapiens
5 MINK1 50488
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 TEX13A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 IZUMO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MMP7 4316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PABPN1L  
Affinity Capture-MS Homo sapiens
11 RAVER1 125950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CNOT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TOB2  
Affinity Capture-MS Homo sapiens
14 XPO1 7514
Affinity Capture-MS Homo sapiens
15 RC3H2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CPEB1  
Proximity Label-MS Homo sapiens
17 D2HGDH 728294
Affinity Capture-MS Homo sapiens
18 RQCD1 9125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BTG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TMEM131  
Affinity Capture-MS Homo sapiens
21 GADD45B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CNOT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TIMM10B 26515
Affinity Capture-MS Homo sapiens
25 MAP4K4 9448
Affinity Capture-MS Homo sapiens
26 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
27 RNF219  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
28 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 G3BP2 9908
Affinity Capture-MS Homo sapiens
30 FASN 2194
Negative Genetic Homo sapiens
31 CNOT3 4849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MAGEA9  
Affinity Capture-MS Homo sapiens
33 DUSP16  
Affinity Capture-MS Homo sapiens
34 GGNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FHL2 2274
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
37 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 Cnot3 232791
Affinity Capture-MS Mus musculus
39 CNOT10 25904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CNOT6L 246175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FANCD2OS  
Affinity Capture-MS Homo sapiens
43 CNOT1 23019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CNOT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DYRK1A 1859
Affinity Capture-MS Homo sapiens
46 OGT 8473
Reconstituted Complex Homo sapiens
47 SCGN  
Affinity Capture-MS Homo sapiens
48 RIBC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CT55  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FAM193B 54540
Two-hybrid Homo sapiens
51 Cnot2  
Affinity Capture-MS Mus musculus
52 NFKB1 4790
Affinity Capture-MS Homo sapiens
53 NPM1 4869
Affinity Capture-MS Homo sapiens
54 TBC1D10A 83874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GPBP1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
56 GLA 2717
Affinity Capture-MS Homo sapiens
57 TOB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 NANOS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CCT8L2  
Affinity Capture-MS Homo sapiens
60 THRSP  
Affinity Capture-MS Homo sapiens
61 NANOS1 340719
Affinity Capture-MS Homo sapiens
62 ALS2CR11  
Two-hybrid Homo sapiens
63 NLK  
Affinity Capture-MS Homo sapiens
64 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 EDRF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 DGCR2 9993
Affinity Capture-MS Homo sapiens
67 CAPZA1 829
Affinity Capture-MS Homo sapiens
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