Gene description for AMPD3
Gene name adenosine monophosphate deaminase 3
Gene symbol AMPD3
Other names/aliases -
Species Homo sapiens
 Database cross references - AMPD3
ExoCarta ExoCarta_272
Vesiclepedia VP_272
Entrez Gene 272
HGNC 470
MIM 102772
UniProt Q01432  
 AMPD3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for AMPD3
Molecular Function
    AMP deaminase activity GO:0003876 IBA
    AMP deaminase activity GO:0003876 ISS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    IMP biosynthetic process GO:0006188 IBA
    AMP catabolic process GO:0006196 TAS
    IMP salvage GO:0032264 IEA
    AMP metabolic process GO:0046033 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    secretory granule lumen GO:0034774 TAS
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified AMPD3 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AMPD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNIP1  
Two-hybrid Homo sapiens
2 ALB 213
Affinity Capture-MS Homo sapiens
3 AMPD1  
Two-hybrid Homo sapiens
4 TTC14  
Affinity Capture-MS Homo sapiens
5 AMPD2 271
Affinity Capture-MS Homo sapiens
6 ITGB2 3689
Affinity Capture-MS Homo sapiens
7 CCR1  
Affinity Capture-MS Homo sapiens
8 RAD21 5885
Affinity Capture-Western Homo sapiens
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