Gene description for SLCO4C1
Gene name solute carrier organic anion transporter family, member 4C1
Gene symbol SLCO4C1
Other names/aliases OATP-H
OATP-M1
OATP4C1
OATPX
PRO2176
SLC21A20
Species Homo sapiens
 Database cross references - SLCO4C1
ExoCarta ExoCarta_353189
Vesiclepedia VP_353189
Entrez Gene 353189
HGNC 23612
MIM 609013
UniProt Q6ZQN7  
 SLCO4C1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for SLCO4C1
Molecular Function
    organic anion transmembrane transporter activity GO:0008514 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IBA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 TAS
Biological Process
    monoatomic ion transport GO:0006811 IEA
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
    sodium-independent organic anion transport GO:0043252 IBA
    sodium-independent organic anion transport GO:0043252 TAS
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IBA
    azurophil granule membrane GO:0035577 TAS
    specific granule membrane GO:0035579 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLCO4C1 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLCO4C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MFSD12  
Affinity Capture-MS Homo sapiens
2 PTPRD 5789
Affinity Capture-MS Homo sapiens
3 CLGN 1047
Affinity Capture-MS Homo sapiens
4 ABCB8 11194
Affinity Capture-MS Homo sapiens
5 CANX 821
Affinity Capture-MS Homo sapiens
6 ST7L  
Affinity Capture-MS Homo sapiens
7 LAMTOR1 55004
Proximity Label-MS Homo sapiens
8 MTX1 4580
Affinity Capture-MS Homo sapiens
9 PDK1 5163
Affinity Capture-MS Homo sapiens
10 HLTF  
Affinity Capture-MS Homo sapiens
11 ATP12A 479
Affinity Capture-MS Homo sapiens
12 DSC1 1823
Affinity Capture-MS Homo sapiens
13 PDXDC1 23042
Affinity Capture-MS Homo sapiens
14 HECW2  
Affinity Capture-MS Homo sapiens
15 KCNT2  
Affinity Capture-MS Homo sapiens
16 SLC9A1 6548
Affinity Capture-MS Homo sapiens
17 RAB11A 8766
Proximity Label-MS Homo sapiens
18 CBWD3  
Affinity Capture-MS Homo sapiens
19 SLC45A1  
Affinity Capture-MS Homo sapiens
20 NR2F2  
Affinity Capture-MS Homo sapiens
21 SLC47A1  
Affinity Capture-MS Homo sapiens
22 ABHD17B 51104
Affinity Capture-MS Homo sapiens
23 ATP11C 286410
Affinity Capture-MS Homo sapiens
24 ATP2C1 27032
Affinity Capture-MS Homo sapiens
25 ADIPOR1 51094
Affinity Capture-MS Homo sapiens
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