Gene description for CXCL8
Gene name	chemokine (C-X-C motif) ligand 8
Gene symbol	CXCL8
Other names/aliases	GCP-1 GCP1 IL8 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1
Species	Homo sapiens
Database cross references - CXCL8
ExoCarta	ExoCarta_3576
Vesiclepedia	VP_3576
Entrez Gene	3576
HGNC	6025
MIM	146930
UniProt	P10145
CXCL8 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for CXCL8

Molecular Function     interleukin-8 receptor binding GO:0005153 IPI     protein binding GO:0005515 IPI     chemokine activity GO:0008009 IBA     chemokine activity GO:0008009 IDA     chemokine activity GO:0008009 TAS     heparin binding GO:0008201 IDA     CXCR chemokine receptor binding GO:0045236 IBA Biological Process     angiogenesis GO:0001525 TAS     response to molecule of bacterial origin GO:0002237 IDA     chemotaxis GO:0006935 TAS     inflammatory response GO:0006954 IBA     inflammatory response GO:0006954 TAS     signal transduction GO:0007165 TAS     G protein-coupled receptor signaling pathway GO:0007186 TAS     negative regulation of cell population proliferation GO:0008285 TAS     positive regulation of biosynthetic process GO:0009891 IDA     positive regulation of gene expression GO:0010628 IDA     negative regulation of gene expression GO:0010629 IDA     calcium-mediated signaling GO:0019722 TAS     regulation of cell adhesion GO:0030155 IDA     neutrophil chemotaxis GO:0030593 IBA     neutrophil chemotaxis GO:0030593 IDA     neutrophil chemotaxis GO:0030593 IGI     receptor internalization GO:0031623 IDA     killing of cells of another organism GO:0031640 IDA     response to endoplasmic reticulum stress GO:0034976 IDA     intracellular signal transduction GO:0035556 IDA     neutrophil activation GO:0042119 IDA     neutrophil activation GO:0042119 TAS     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045091 IDA     negative regulation of G protein-coupled receptor signaling pathway GO:0045744 IDA     positive regulation of angiogenesis GO:0045766 IDA     embryonic digestive tract development GO:0048566 IEP     induction of positive chemotaxis GO:0050930 IGI     negative regulation of cell adhesion molecule production GO:0060354 IDA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA     cellular response to lipopolysaccharide GO:0071222 IBA     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to interleukin-1 GO:0071347 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     positive regulation of neutrophil chemotaxis GO:0090023 TAS     regulation of entry of bacterium into host cell GO:2000535 IMP Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA