Gene description for AREG
Gene name	amphiregulin
Gene symbol	AREG
Other names/aliases	AR AREGB CRDGF SDGF
Species	Homo sapiens
Database cross references - AREG
ExoCarta	ExoCarta_374
Vesiclepedia	VP_374
Entrez Gene	374
HGNC	651
MIM	104640
UniProt	P15514
AREG identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34887515
Colorectal cancer cells	34887515
Keratinocytes	19530224
Keratinocytes	19530224

Gene ontology annotations for AREG

Molecular Function     cytokine activity GO:0005125 IEA     epidermal growth factor receptor binding GO:0005154 IBA     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IBA     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 IDA     receptor ligand activity GO:0048018 IDA Biological Process     epidermal growth factor receptor signaling pathway GO:0007173 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IDA     G protein-coupled receptor signaling pathway GO:0007186 IDA     cell-cell signaling GO:0007267 TAS     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of keratinocyte proliferation GO:0010838 TAS     glial cell proliferation GO:0014009 IEA     neuron projection development GO:0031175 IEA     response to estradiol GO:0032355 IEA     ERBB2-EGFR signaling pathway GO:0038134 IDA     response to hydrogen peroxide GO:0042542 IEA     response to peptide hormone GO:0043434 IEA     negative regulation of osteoblast differentiation GO:0045668 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     response to glucocorticoid GO:0051384 IEA     response to cAMP GO:0051591 IEA     dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis GO:0060598 IEA     mammary gland branching involved in thelarche GO:0060744 IEA     mammary gland alveolus development GO:0060749 IEA     epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IDA     nucleus GO:0005634 IEA     endoplasmic reticulum membrane GO:0005789 TAS     cell surface GO:0009986 IDA     ER to Golgi transport vesicle membrane GO:0012507 TAS     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS