Gene description for ORM1
Gene name orosomucoid 1
Gene symbol ORM1
Other names/aliases AGP-A
AGP1
HEL-S-153w
ORM
Species Homo sapiens
 Database cross references - ORM1
ExoCarta ExoCarta_5004
Vesiclepedia VP_5004
Entrez Gene 5004
HGNC 8498
MIM 138600
UniProt P02763  
 ORM1 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Urine 25452312    
 Gene ontology annotations for ORM1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of immune system process GO:0002682 IEA
    acute-phase response GO:0006953 IEA
    inflammatory response GO:0006954 TAS
    negative regulation of interleukin-6 production GO:0032715 IDA
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    positive regulation of interleukin-1 beta production GO:0032731 IDA
    positive regulation of interleukin-1 production GO:0032732 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
Subcellular Localization
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    platelet alpha granule lumen GO:0031093 TAS
    specific granule lumen GO:0035580 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified ORM1 in sEVs
1
Experiment ID 494
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 238
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors "Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R."
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ORM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC1 84624
Affinity Capture-MS Homo sapiens
2 MATN2 4147
Affinity Capture-MS Homo sapiens
3 PGK2 5232
Affinity Capture-MS Homo sapiens
4 SERPINA1 5265
Affinity Capture-MS Homo sapiens
5 HBB 3043
Affinity Capture-MS Homo sapiens
6 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GLUD1 2746
Two-hybrid Homo sapiens
8 STATH  
Affinity Capture-MS Homo sapiens
9 C18orf21  
Affinity Capture-MS Homo sapiens
10 BLVRB 645
Two-hybrid Homo sapiens
11 PTGDS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 AGPAT1 10554
Affinity Capture-MS Homo sapiens
13 SCGB1D1  
Affinity Capture-MS Homo sapiens
14 TMEM37  
Two-hybrid Homo sapiens
15 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ITLN2  
Affinity Capture-MS Homo sapiens
17 GC 2638
Affinity Capture-MS Homo sapiens
18 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GNG8  
Affinity Capture-MS Homo sapiens
20 CIR1  
Affinity Capture-MS Homo sapiens
21 GABRD  
Affinity Capture-MS Homo sapiens
22 FGB 2244
Affinity Capture-MS Homo sapiens
23 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CP 1356
Affinity Capture-MS Homo sapiens
25 EBF2  
Affinity Capture-MS Homo sapiens
26 SERPINE1 5054
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
27 PTDSS1 9791
Affinity Capture-MS Homo sapiens
28 WHSC1 7468
Affinity Capture-MS Homo sapiens
29 CLU 1191
Affinity Capture-MS Homo sapiens
30 AZGP1 563
Affinity Capture-MS Homo sapiens
31 MBNL1 4154
Affinity Capture-MS Homo sapiens
32 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
33 FNDC5  
Affinity Capture-MS Homo sapiens
34 PDE6D 5147
Affinity Capture-MS Homo sapiens
35 TF 7018
Affinity Capture-MS Homo sapiens
36 RHBDD1 84236
Affinity Capture-MS Homo sapiens
37 HPX 3263
Affinity Capture-MS Homo sapiens
38 ORM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HP 3240
Affinity Capture-MS Homo sapiens
41 KLK10 5655
Affinity Capture-MS Homo sapiens
42 SARAF  
Affinity Capture-MS Homo sapiens
43 PRR4 11272
Affinity Capture-MS Homo sapiens
44 PINK1  
Affinity Capture-MS Homo sapiens
45 TP63  
Two-hybrid Homo sapiens
46 EGFL8  
Affinity Capture-MS Homo sapiens
47 SSUH2  
Affinity Capture-MS Homo sapiens
48 LCN1 3933
Affinity Capture-MS Homo sapiens
49 SMIM8  
Affinity Capture-MS Homo sapiens
50 GDPD1 284161
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CCR1  
Affinity Capture-MS Homo sapiens
52 SFXN4  
Affinity Capture-MS Homo sapiens
53 SERPINA3 12
Affinity Capture-MS Homo sapiens
54 GSDMB  
Two-hybrid Homo sapiens
55 STX17 55014
Affinity Capture-MS Homo sapiens
56 P2RX6  
Affinity Capture-MS Homo sapiens
57 RIPPLY3  
Affinity Capture-MS Homo sapiens
58 UBE2U  
Affinity Capture-MS Homo sapiens
59 APOA1 335
Affinity Capture-MS Homo sapiens
60 PIK3R3 8503
Two-hybrid Homo sapiens
61 PHF11 51131
Affinity Capture-MS Homo sapiens
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