Gene description for RRM2B
Gene name ribonucleotide reductase M2 B (TP53 inducible)
Gene symbol RRM2B
Other names/aliases MTDPS8A
MTDPS8B
P53R2
Species Homo sapiens
 Database cross references - RRM2B
ExoCarta ExoCarta_50484
Vesiclepedia VP_50484
Entrez Gene 50484
HGNC 17296
MIM 604712
UniProt Q7LG56  
 RRM2B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RRM2B
Molecular Function
    ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0004748 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    DNA synthesis involved in DNA repair GO:0000731 NAS
    kidney development GO:0001822 IEA
    renal system process GO:0003014 IEA
    mitochondrial DNA replication GO:0006264 IMP
    DNA repair GO:0006281 IDA
    response to oxidative stress GO:0006979 IEA
    ribonucleoside diphosphate metabolic process GO:0009185 IDA
    deoxyribonucleoside triphosphate metabolic process GO:0009200 IEA
    deoxyribonucleotide biosynthetic process GO:0009263 IBA
    2'-deoxyribonucleotide biosynthetic process GO:0009265 IDA
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IDA
    response to amine GO:0014075 IEA
    positive regulation of G0 to G1 transition GO:0070318 IDA
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    ribonucleoside-diphosphate reductase complex GO:0005971 ISS
 Experiment description of studies that identified RRM2B in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RRM2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RRM2 6241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GMFB 2764
Affinity Capture-MS Homo sapiens
3 SIRT6  
Affinity Capture-MS Homo sapiens
4 ORC4  
Two-hybrid Homo sapiens
5 TP53 7157
Affinity Capture-Western Homo sapiens
6 RNF4 6047
Affinity Capture-MS Homo sapiens
7 BAG2 9532
Affinity Capture-MS Homo sapiens
8 INPPL1 3636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TPM2 7169
Affinity Capture-MS Homo sapiens
10 RNF41  
Two-hybrid Homo sapiens
11 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
12 NABP2  
Affinity Capture-MS Homo sapiens
13 ATM 472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 TMEM263 90488
Affinity Capture-MS Homo sapiens
15 ENTPD7  
Affinity Capture-MS Homo sapiens
16 TBC1D32 221322
Proximity Label-MS Homo sapiens
17 HSPA2 3306
Affinity Capture-MS Homo sapiens
18 RRM1 6240
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MCM2 4171
Affinity Capture-MS Homo sapiens
20 TMOD2 29767
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ZNF131  
Affinity Capture-MS Homo sapiens
22 SPAG9 9043
Affinity Capture-MS Homo sapiens
23 RRM2B 50484
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 FZR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MDM2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
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