Gene description for TMEM14C
Gene name transmembrane protein 14C
Gene symbol TMEM14C
Other names/aliases C6orf53
HSPC194
MSTP073
NET26
bA421M1.6
Species Homo sapiens
 Database cross references - TMEM14C
ExoCarta ExoCarta_51522
Vesiclepedia VP_51522
Entrez Gene 51522
HGNC 20952
MIM 615318
UniProt Q9P0S9  
 TMEM14C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM14C
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    heme biosynthetic process GO:0006783 IEA
    mitochondrial transport GO:0006839 IEA
    erythrocyte differentiation GO:0030218 IEA
    regulation of heme biosynthetic process GO:0070453 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial membrane GO:0031966 IBA
 Experiment description of studies that identified TMEM14C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM14C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM35  
Two-hybrid Homo sapiens
2 TMEM52B 120939
Two-hybrid Homo sapiens
3 RSG1  
Two-hybrid Homo sapiens
4 NDUFA11 126328
Co-fractionation Homo sapiens
5 SDC3  
Two-hybrid Homo sapiens
6 SLC10A6  
Two-hybrid Homo sapiens
7 SSMEM1  
Two-hybrid Homo sapiens
8 MTERF3  
Two-hybrid Homo sapiens
9 ELOVL7 79993
Two-hybrid Homo sapiens
10 ZFYVE27 118813
Two-hybrid Homo sapiens
11 MARCH8  
Two-hybrid Homo sapiens
12 CRELD1 78987
Affinity Capture-MS Homo sapiens
13 TMEM14B  
Two-hybrid Homo sapiens
14 TMEM86B  
Two-hybrid Homo sapiens
15 RCHY1  
Two-hybrid Homo sapiens
16 EBP  
Two-hybrid Homo sapiens
17 HSD17B13  
Two-hybrid Homo sapiens
18 DDX58 23586
Affinity Capture-RNA Homo sapiens
19 CREB3L1  
Two-hybrid Homo sapiens
20 MMGT1 93380
Two-hybrid Homo sapiens
21 SFXN1 94081
Co-fractionation Homo sapiens
22 GJB1 2705
Two-hybrid Homo sapiens
23 GORAB 92344
Two-hybrid Homo sapiens
24 FAM209A 200232
Two-hybrid Homo sapiens
25 CLDN5 7122
Two-hybrid Homo sapiens
26 CCDC155  
Two-hybrid Homo sapiens
27 GPR152  
Two-hybrid Homo sapiens
28 NDUFS3 4722
Co-fractionation Homo sapiens
29 LNX1  
Two-hybrid Homo sapiens
30 STX1A 6804
Two-hybrid Homo sapiens
31 TMEM79  
Two-hybrid Homo sapiens
32 PDZK1IP1 10158
Two-hybrid Homo sapiens
33 NCR3LG1 374383
Two-hybrid Homo sapiens
34 PLIN3 10226
Two-hybrid Homo sapiens
35 CREB3  
Two-hybrid Homo sapiens
36 C10orf54 64115
Two-hybrid Homo sapiens
37 MUC1 4582
Two-hybrid Homo sapiens
38 TMEM31  
Two-hybrid Homo sapiens
39 ARL13B 200894
Two-hybrid Homo sapiens
40 MFF 56947
Two-hybrid Homo sapiens
41 ZDHHC15 158866
Two-hybrid Homo sapiens
42 SPCS2 9789
Co-fractionation Homo sapiens
43 TMX2 51075
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM14C is involved
No pathways found





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