Gene description for Actr1a
Gene name ARP1 actin-related protein 1A, centractin alpha
Gene symbol Actr1a
Other names/aliases Arp1
alpha-Arp1
Species Mus musculus
 Database cross references - Actr1a
ExoCarta ExoCarta_54130
Vesiclepedia VP_54130
Entrez Gene 54130
UniProt P61164  
 Actr1a identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Actr1a
Molecular Function
    ATP binding GO:0005524 IEA
Subcellular Localization
    manchette GO:0002177 ISO
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    centriole GO:0005814 ISO
    dynactin complex GO:0005869 IBA
    cell cortex GO:0005938 IEA
    cell cortex GO:0005938 ISO
    microtubule cytoskeleton GO:0015630 ISO
    COPI-coated vesicle GO:0030137 ISO
    myelin sheath GO:0043209 HDA
 Experiment description of studies that identified Actr1a in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Actr1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCTN1 1639
Affinity Capture-MS Homo sapiens
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Mettl21e  
Affinity Capture-MS Mus musculus
4 Inpp5d 16331
Affinity Capture-MS Mus musculus
5 SNCA 6622
Affinity Capture-MS Homo sapiens
6 Fmr1  
Affinity Capture-MS Mus musculus
7 ACTR1A 10121
Affinity Capture-MS Homo sapiens
8 Eed  
Affinity Capture-MS Mus musculus
9 DCTN2 10540
Affinity Capture-MS Homo sapiens
10 ACTR1B 10120
Affinity Capture-MS Homo sapiens
11 Tnik  
Affinity Capture-MS Mus musculus
12 Atxn1  
Affinity Capture-MS Mus musculus
13 ACTR10 55860
Affinity Capture-MS Homo sapiens
14 Bcl2  
Affinity Capture-MS Mus musculus
15 DCTN4 51164
Affinity Capture-MS Homo sapiens
16 DCTN3 11258
Affinity Capture-MS Homo sapiens
17 DCTN6 10671
Affinity Capture-MS Homo sapiens
18 DCTN5 84516
Affinity Capture-MS Homo sapiens
19 Mapt  
Affinity Capture-MS Mus musculus
20 Ywhae 22627
Affinity Capture-MS Mus musculus
21 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Actr1a is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Anchoring of the basal body to the plasma membrane IEA Reactome
Asparagine N-linked glycosylation IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Centrosome maturation IEA Reactome
Cilium Assembly IEA Reactome
COPI-independent Golgi-to-ER retrograde traffic IEA Reactome
COPI-mediated anterograde transport IEA Reactome
ER to Golgi Anterograde Transport IEA Reactome
G2/M Transition IEA Reactome
Golgi-to-ER retrograde transport IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism of proteins IEA Reactome
MHC class II antigen presentation IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Prometaphase IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
Post-translational protein modification IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
Transport to the Golgi and subsequent modification IEA Reactome
Vesicle-mediated transport IEA Reactome





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