Gene description for ACTR10
Gene name actin-related protein 10 homolog (S. cerevisiae)
Gene symbol ACTR10
Other names/aliases ACTR11
Arp10
Arp11
HARP11
Species Homo sapiens
 Database cross references - ACTR10
ExoCarta ExoCarta_55860
Vesiclepedia VP_55860
Entrez Gene 55860
HGNC 17372
UniProt Q9NZ32  
 ACTR10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ACTR10
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde axonal transport of mitochondrion GO:0098958 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytosol GO:0005829 TAS
    dynactin complex GO:0005869 IBA
    azurophil granule lumen GO:0035578 TAS
    axon cytoplasm GO:1904115 IEA
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified ACTR10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACTR10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Affinity Capture-MS Homo sapiens
2 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
3 NAGK 55577
Two-hybrid Homo sapiens
4 Dctn5  
Affinity Capture-MS Mus musculus
5 RPS6KA2  
Affinity Capture-MS Homo sapiens
6 NEXN 91624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DCTN3 11258
Co-fractionation Homo sapiens
8 RIT1 6016
Negative Genetic Homo sapiens
9 SEPT14  
Affinity Capture-MS Homo sapiens
10 CA10  
Affinity Capture-MS Homo sapiens
11 CLIP1 6249
Affinity Capture-MS Homo sapiens
12 PDGFD 80310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 C9orf24  
Affinity Capture-MS Homo sapiens
14 ABRA  
Affinity Capture-MS Homo sapiens
15 Dctn1 13191
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
16 DCTN6 10671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CXCL14  
Affinity Capture-MS Homo sapiens
18 LMNB1 4001
Co-fractionation Homo sapiens
19 RHOC 389
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RPS19BP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 C1orf106  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CCDC120  
Affinity Capture-MS Homo sapiens
23 KLC3  
Affinity Capture-MS Homo sapiens
24 MAPK8IP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 Capza1 12340
Affinity Capture-MS Mus musculus
26 ACTC1 70
Affinity Capture-MS Homo sapiens
27 SOX2  
Affinity Capture-MS Homo sapiens
28 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
29 NGEF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DYNC1I1  
Proximity Label-MS Homo sapiens
31 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TUBB4B 10383
Affinity Capture-MS Homo sapiens
34 ACTR1B 10120
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DCTN2 10540
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MYO19  
Affinity Capture-MS Homo sapiens
37 CSPP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
39 DCTN5 84516
Affinity Capture-MS Homo sapiens
40 Actb 11461
Affinity Capture-MS Mus musculus
41 C16orf45  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 AKAP1 8165
Cross-Linking-MS (XL-MS) Homo sapiens
43 RABEP1 9135
Co-fractionation Homo sapiens
44 RIC8A 60626
Affinity Capture-MS Homo sapiens
45 DYNC1I2 1781
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MAPRE1 22919
Affinity Capture-MS Homo sapiens
47 DUSP13  
Affinity Capture-MS Homo sapiens
48 N4BP2L1  
Affinity Capture-MS Homo sapiens
49 Dctn2 69654
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
50 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACTG1 71
Affinity Capture-MS Homo sapiens
52 Actr1b 226977
Affinity Capture-MS Mus musculus
53 Dctn3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
54 NIN 51199
Proximity Label-MS Homo sapiens
55 BCL7C  
Affinity Capture-MS Homo sapiens
56 LOC554223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CCL4L1  
Affinity Capture-MS Homo sapiens
58 RAB7A 7879
Proximity Label-MS Homo sapiens
59 DCTN4 51164
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
60 RAB11A 8766
Proximity Label-MS Homo sapiens
61 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
62 AKR7A2 8574
Affinity Capture-MS Homo sapiens
63 DEFB127  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 DCTN1 1639
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RXFP4  
Two-hybrid Homo sapiens
66 KIF11 3832
Affinity Capture-MS Homo sapiens
67 ACTB 60
Affinity Capture-MS Homo sapiens
68 Actr1a 54130
Affinity Capture-MS Mus musculus
69 CAPZA1 829
Affinity Capture-MS Homo sapiens
70 ACTR1A 10121
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
71 MIS18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 HOMEZ  
Two-hybrid Homo sapiens
73 UQCRH 7388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
75 ORC6  
Affinity Capture-MS Homo sapiens
76 KRAS 3845
Negative Genetic Homo sapiens
77 DYNLL1 8655
Affinity Capture-MS Homo sapiens
78 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
79 MED22  
Affinity Capture-MS Homo sapiens
80 KLHL2 11275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 Dctn4  
Affinity Capture-MS Mus musculus
82 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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