Gene description for CNTLN
Gene name centlein, centrosomal protein
Gene symbol CNTLN
Other names/aliases C9orf101
C9orf39
bA340N12.1
Species Homo sapiens
 Database cross references - CNTLN
ExoCarta ExoCarta_54875
Vesiclepedia VP_54875
Entrez Gene 54875
HGNC 23432
MIM 611870
UniProt Q9NXG0  
 CNTLN identified in sEVs derived from the following tissue/cell type
Mesothelioma cells 15111327    
Urine 19056867    
 Gene ontology annotations for CNTLN
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    protein domain specific binding GO:0019904 IPI
    protein-macromolecule adaptor activity GO:0030674 IMP
Biological Process
    spermatogenesis GO:0007283 IEA
    single fertilization GO:0007338 IEA
    centriole-centriole cohesion GO:0010457 IBA
    centriole-centriole cohesion GO:0010457 IMP
    regulation of protein localization GO:0032880 IEA
    protein localization to organelle GO:0033365 IBA
    protein localization to organelle GO:0033365 IMP
    protein-containing complex assembly GO:0065003 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    centriole GO:0005814 IBA
    centriole GO:0005814 IDA
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 HDA
    sperm head-tail coupling apparatus GO:0120212 IEA
 Experiment description of studies that identified CNTLN in sEVs
1
Experiment ID 25
MISEV standards
IEM
Biophysical techniques
HSP90|beta-tubulin
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15111327    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes secreted by human mesothelioma cells.
Authors "Hegmans JP, Bard MP, Hemmes A, Luider TM, Kleijmeer MJ, Prins JB, Zitvogel L, Burgers SA, Hoogsteden HC, Lambrecht BN."
Journal name AJP
Publication year 2004
Sample Mesothelioma cells
Sample name PMR-MM7
PMR-MM8
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CNTLN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Affinity Capture-MS Homo sapiens
2 Cep152  
Affinity Capture-MS Mus musculus
3 Mus81  
Affinity Capture-MS Mus musculus
4 SP1  
Affinity Capture-MS Homo sapiens
5 Tnpo1 238799
Affinity Capture-MS Mus musculus
6 NDC80 10403
Proximity Label-MS Homo sapiens
7 YWHAG 7532
Affinity Capture-MS Homo sapiens
8 BRCA1 672
Two-hybrid Homo sapiens
9 PCM1 5108
Proximity Label-MS Homo sapiens
10 TPM1 7168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 YWHAE 7531
Affinity Capture-MS Homo sapiens
12 Ndc80  
Affinity Capture-MS Mus musculus
13 C18orf54  
Affinity Capture-MS Homo sapiens
14 ATG101  
Affinity Capture-MS Homo sapiens
15 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PPP5C 5536
Affinity Capture-MS Homo sapiens
17 CEP135  
Proximity Label-MS Homo sapiens
18 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NINL  
Proximity Label-MS Homo sapiens
20 PRSS12 8492
Affinity Capture-MS Homo sapiens
21 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CNTLN is involved
No pathways found





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