Gene description for AVPR1A
Gene name arginine vasopressin receptor 1A
Gene symbol AVPR1A
Other names/aliases AVPR V1a
AVPR1
V1aR
Species Homo sapiens
 Database cross references - AVPR1A
ExoCarta ExoCarta_552
Vesiclepedia VP_552
Entrez Gene 552
HGNC 895
MIM 600821
UniProt P37288  
 AVPR1A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AVPR1A
Molecular Function
    vasopressin receptor activity GO:0005000 IBA
    vasopressin receptor activity GO:0005000 IDA
    protein kinase C binding GO:0005080 TAS
    protein binding GO:0005515 IPI
    peptide hormone binding GO:0017046 IEA
    V1A vasopressin receptor binding GO:0031894 IEA
Biological Process
    regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA
    maternal aggressive behavior GO:0002125 IEA
    positive regulation of systemic arterial blood pressure GO:0003084 IEA
    generation of precursor metabolites and energy GO:0006091 TAS
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    negative regulation of female receptivity GO:0007621 IEA
    grooming behavior GO:0007625 IEA
    blood circulation GO:0008015 TAS
    positive regulation of cell population proliferation GO:0008284 IEA
    positive regulation of heart rate GO:0010460 IEA
    positive regulation of glutamate secretion GO:0014049 IEA
    myotube differentiation GO:0014902 IEA
    calcium-mediated signaling GO:0019722 IEA
    telencephalon development GO:0021537 IEA
    positive regulation of cell growth GO:0030307 IEA
    positive regulation of prostaglandin biosynthetic process GO:0031394 IEA
    positive regulation of cellular pH reduction GO:0032849 IEA
    cellular response to hormone stimulus GO:0032870 IBA
    social behavior GO:0035176 IEA
    cellular response to water deprivation GO:0042631 IEA
    maternal behavior GO:0042711 IEA
    sperm ejaculation GO:0042713 IEA
    positive regulation of vasoconstriction GO:0045907 IBA
    response to corticosterone GO:0051412 IEA
    negative regulation of transmission of nerve impulse GO:0051970 IEA
    transport across blood-brain barrier GO:0150104 NAS
Subcellular Localization
    endosome GO:0005768 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    endocytic vesicle GO:0030139 IDA
 Experiment description of studies that identified AVPR1A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AVPR1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKCA 5578
Affinity Capture-Western Homo sapiens
2 PSMD14 10213
Affinity Capture-MS Homo sapiens
3 GRK5 2869
Affinity Capture-Western Homo sapiens
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