Gene description for VIMP
Gene name VCP-interacting membrane selenoprotein
Gene symbol VIMP
Other names/aliases AD-015
ADO15
SBBI8
SELS
SEPS1
Species Homo sapiens
 Database cross references - VIMP
ExoCarta ExoCarta_55829
Vesiclepedia VP_55829
Entrez Gene 55829
HGNC 30396
MIM 607918
UniProt Q9BQE4  
 VIMP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VIMP
Molecular Function
    protein binding GO:0005515 IPI
    antioxidant activity GO:0016209 IDA
    enzyme binding GO:0019899 IPI
    signaling receptor activity GO:0038023 NAS
    ATPase binding GO:0051117 IPI
    ubiquitin-specific protease binding GO:1990381 IPI
Biological Process
    negative regulation of acute inflammatory response to antigenic stimulus GO:0002865 IMP
    regulation of gluconeogenesis GO:0006111 TAS
    ER overload response GO:0006983 IDA
    ER overload response GO:0006983 IMP
    response to glucose GO:0009749 IEP
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    retrograde protein transport, ER to cytosol GO:0030970 IBA
    retrograde protein transport, ER to cytosol GO:0030970 IDA
    negative regulation of interleukin-6 production GO:0032715 ISS
    negative regulation of tumor necrosis factor production GO:0032720 ISS
    cellular response to insulin stimulus GO:0032869 TAS
    cellular response to oxidative stress GO:0034599 IMP
    ERAD pathway GO:0036503 IDA
    establishment of protein localization GO:0045184 TAS
    cell redox homeostasis GO:0045454 IDA
    negative regulation of glycogen biosynthetic process GO:0045719 TAS
    negative regulation of D-glucose import GO:0046325 TAS
    negative regulation of inflammatory response GO:0050728 IC
    response to redox state GO:0051775 IDA
    cellular response to lipopolysaccharide GO:0071222 IMP
    regulation of nitric oxide metabolic process GO:0080164 IMP
    cellular oxidant detoxification GO:0098869 IEA
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP
    negative regulation of macrophage apoptotic process GO:2000110 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytoplasmic microtubule GO:0005881 IDA
    plasma membrane GO:0005886 TAS
    very-low-density lipoprotein particle GO:0034361 IDA
    low-density lipoprotein particle GO:0034362 IDA
    Derlin-1-VIMP complex GO:0036502 IBA
    Derlin-1-VIMP complex GO:0036502 IDA
    Derlin-1 retrotranslocation complex GO:0036513 IBA
    Derlin-1 retrotranslocation complex GO:0036513 IDA
 Experiment description of studies that identified VIMP in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VIMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UFD1L 7353
Affinity Capture-Western Homo sapiens
2 NPLOC4 55666
Affinity Capture-Western Homo sapiens
3 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DERL2 51009
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LRRC59 55379
Proximity Label-MS Homo sapiens
7 SRPK2 6733
Biochemical Activity Homo sapiens
8 SNTG2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 KIAA1715 80856
Proximity Label-MS Homo sapiens
10 APOB 338
Affinity Capture-Western Homo sapiens
11 KPNB1 3837
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 FOXA1  
Affinity Capture-MS Homo sapiens
13 UBE4A 9354
Affinity Capture-MS Homo sapiens
14 KLHDC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PTGS2 5743
Affinity Capture-Western Homo sapiens
16 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 APOA5 116519
Two-hybrid Homo sapiens
18 SCN4A  
Affinity Capture-MS Homo sapiens
19 SAAL1 113174
Affinity Capture-MS Homo sapiens
20 UBXN8  
Affinity Capture-MS Homo sapiens
21 SEC62 7095
Proximity Label-MS Homo sapiens
22 C16orf58 64755
Affinity Capture-MS Homo sapiens
23 ATP2A1 487
Proximity Label-MS Homo sapiens
24 C16orf72 29035
Affinity Capture-MS Homo sapiens
25 AMFR 267
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 HSPA4 3308
Affinity Capture-Western Homo sapiens
27 SAA1 6288
Reconstituted Complex Homo sapiens
28 SELK  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
29 TMEM129  
Affinity Capture-Western Homo sapiens
30 CKAP4 10970
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
31 CAV1 857
Affinity Capture-Western Homo sapiens
32 CYCS 54205
Affinity Capture-MS Homo sapiens
33 SEC61B 10952
Proximity Label-MS Homo sapiens
34 SVIP 258010
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 HUWE1 10075
Affinity Capture-MS Homo sapiens
36 HERPUD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 DERL1 79139
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
38 VCP 7415
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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