Gene description for Rab2a
Gene name RAB2A, member RAS oncogene family
Gene symbol Rab2a
Other names/aliases 9330148M11Rik
C80220
Rab2
Species Mus musculus
 Database cross references - Rab2a
ExoCarta ExoCarta_59021
Vesiclepedia VP_59021
Entrez Gene 59021
UniProt P53994  
 Rab2a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rab2a
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    GDP binding GO:0019003 ISO
    GDP binding GO:0019003 ISS
Biological Process
    intracellular protein transport GO:0006886 TAS
    Golgi organization GO:0007030 ISO
    Golgi organization GO:0007030 ISS
    vesicle-mediated transport GO:0016192 IBA
    vesicle-mediated transport GO:0016192 IEA
    macroautophagy GO:0016236 IMP
    macroautophagy GO:0016236 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    autophagosome membrane GO:0000421 IDA
    acrosomal vesicle GO:0001669 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 ISO
    synaptic vesicle membrane GO:0030672 ISO
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    melanosome GO:0042470 IEA
    neuronal cell body GO:0043025 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Rab2a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rab2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Lmna 16905
Affinity Capture-MS Mus musculus
4 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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