Gene description for Erbb2ip
Gene name Erbb2 interacting protein
Gene symbol Erbb2ip
Other names/aliases 1700028E05Rik
Erbin
mKIAA1225
Species Mus musculus
 Database cross references - Erbb2ip
ExoCarta ExoCarta_59079
Vesiclepedia VP_59079
Entrez Gene 59079
UniProt Q80TH2  
 Erbb2ip identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Erbb2ip
Molecular Function
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
Biological Process
    protein targeting GO:0006605 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
    response to muramyl dipeptide GO:0032495 IEA
    response to muramyl dipeptide GO:0032495 ISO
    response to lipopolysaccharide GO:0032496 IEA
    response to lipopolysaccharide GO:0032496 ISO
    intracellular signal transduction GO:0035556 IBA
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 IBA
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 IMP
    negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070433 ISO
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to tumor necrosis factor GO:0071356 ISO
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 IMP
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IDA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    cell junction GO:0030054 ISO
    hemidesmosome GO:0030056 IEA
    hemidesmosome GO:0030056 ISO
    neuromuscular junction GO:0031594 IEA
    neuromuscular junction GO:0031594 ISO
    nuclear membrane GO:0031965 IEA
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
    postsynaptic specialization GO:0099572 IEA
    postsynaptic specialization GO:0099572 ISO
 Experiment description of studies that identified Erbb2ip in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Erbb2ip
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ctnnd1 12388
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Lgr5  
Co-fractionation Mus musculus
4 Arvcf  
Co-fractionation Mus musculus
5 Pkp4  
Affinity Capture-Western Mus musculus
6 Lrrc8b 433926
Co-fractionation Mus musculus
7 Lrch1  
Co-fractionation Mus musculus
8 Slc5a6  
Co-fractionation Mus musculus
9 Lrrc7  
Co-fractionation Mus musculus
10 Kctd13  
Affinity Capture-MS Mus musculus
11 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
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