Gene description for RGS3
Gene name regulator of G-protein signaling 3
Gene symbol RGS3
Other names/aliases C2PA
RGP3
Species Homo sapiens
 Database cross references - RGS3
ExoCarta ExoCarta_5998
Vesiclepedia VP_5998
Entrez Gene 5998
HGNC 9999
MIM 602189
UniProt P49796  
 RGS3 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for RGS3
Molecular Function
    GTPase activity GO:0003924 TAS
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    regulation of G protein-coupled receptor signaling pathway GO:0008277 TAS
    negative regulation of signal transduction GO:0009968 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified RGS3 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACD  
Two-hybrid Homo sapiens
2 DEPDC1B 55789
Two-hybrid Homo sapiens
3 KIAA0232 9778
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PDLIM7 9260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ISG15 9636
Affinity Capture-MS Homo sapiens
6 ZNF24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CYSRT1 375791
Two-hybrid Homo sapiens
8 ALOXE3  
Affinity Capture-MS Homo sapiens
9 ATG9A 79065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 YWHAB 7529
Affinity Capture-Western Homo sapiens
11 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SEPT10 151011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ISCA2 122961
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 REL 5966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ZKSCAN8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ISCA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 YWHAZ 7534
Affinity Capture-Western Homo sapiens
18 EFNB1 1947
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PLSCR1 5359
Two-hybrid Homo sapiens
20 RBAK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KLHL23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ARID3B  
Affinity Capture-MS Homo sapiens
23 Ywhae 22627
Two-hybrid Mus musculus
24 SEPT2 4735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 APP 351
Reconstituted Complex Homo sapiens
26 Ywhaq 22630
Two-hybrid Mus musculus
27 SKAP2 8935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CEP44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ZNF446  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CRAT 1384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HES4  
Reconstituted Complex Homo sapiens
32 GNA11 2767
Affinity Capture-Western Homo sapiens
33 CORO2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 IRF5  
Affinity Capture-MS Homo sapiens
35 ARRB1 408
Affinity Capture-MS Homo sapiens
36 Nedd4 25489
Biochemical Activity Rattus norvegicus
37 KLHL24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 ZNF629 23361
Affinity Capture-MS Homo sapiens
40 ZNF397  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZNF460  
Affinity Capture-MS Homo sapiens
43 SEPT11 55752
Affinity Capture-MS Homo sapiens
44 CKAP4 10970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 UACA 55075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CEP72  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 EFNB3 1949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZSCAN30  
Affinity Capture-MS Homo sapiens
50 SEPT8 23176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 KCTD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 GNAI3 2773
Affinity Capture-Western Homo sapiens
53 ZNF646  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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