Gene description for TSPAN31
Gene name tetraspanin 31
Gene symbol TSPAN31
Other names/aliases SAS
Species Homo sapiens
 Database cross references - TSPAN31
ExoCarta ExoCarta_6302
Vesiclepedia VP_6302
Entrez Gene 6302
HGNC 10539
MIM 181035
UniProt Q12999  
 TSPAN31 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TSPAN31
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of cell population proliferation GO:0008284 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified TSPAN31 in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TSPAN31
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MFSD12  
Affinity Capture-MS Homo sapiens
2 ARV1  
Affinity Capture-MS Homo sapiens
3 LAPTM4B  
Affinity Capture-MS Homo sapiens
4 GPR89A  
Affinity Capture-MS Homo sapiens
5 MFSD1 64747
Affinity Capture-MS Homo sapiens
6 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
7 ATP5F1 515
Affinity Capture-MS Homo sapiens
8 GJA1 2697
Affinity Capture-MS Homo sapiens
9 ZDHHC7  
Affinity Capture-MS Homo sapiens
10 LGALS3 3958
Affinity Capture-MS Homo sapiens
11 SLC35F2 54733
Affinity Capture-MS Homo sapiens
12 MPZL1 9019
Affinity Capture-MS Homo sapiens
13 TMEM120B  
Affinity Capture-MS Homo sapiens
14 VAMP3 9341
Affinity Capture-MS Homo sapiens
15 TSPAN15 23555
Affinity Capture-MS Homo sapiens
16 FITM2  
Affinity Capture-MS Homo sapiens
17 MKRN3  
Affinity Capture-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 PTPN2 5771
Affinity Capture-MS Homo sapiens
20 NRM 11270
Affinity Capture-MS Homo sapiens
21 FXYD6  
Affinity Capture-MS Homo sapiens
22 PTPN1 5770
Affinity Capture-MS Homo sapiens
23 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
24 STX4 6810
Affinity Capture-MS Homo sapiens
25 DDX58 23586
Affinity Capture-RNA Homo sapiens
26 TSPAN2 10100
Two-hybrid Homo sapiens
27 FAM162A 26355
Affinity Capture-MS Homo sapiens
28 XPO5 57510
Affinity Capture-MS Homo sapiens
29 B4GALT7 11285
Affinity Capture-MS Homo sapiens
30 ALG3 10195
Affinity Capture-MS Homo sapiens
31 BCL2L13 23786
Affinity Capture-MS Homo sapiens
32 FAM134C 162427
Affinity Capture-MS Homo sapiens
33 DAGLB 221955
Affinity Capture-MS Homo sapiens
34 SPCS1 28972
Affinity Capture-MS Homo sapiens
35 ALG14  
Affinity Capture-MS Homo sapiens
36 CMTM5  
Two-hybrid Homo sapiens
37 POMK  
Affinity Capture-MS Homo sapiens
38 FAM134A 79137
Affinity Capture-MS Homo sapiens
39 HSDL1 83693
Affinity Capture-MS Homo sapiens
40 ATP1B2  
Affinity Capture-MS Homo sapiens
41 SLC7A2 6542
Affinity Capture-MS Homo sapiens
42 CD81 975
Affinity Capture-MS Homo sapiens
43 DNAJC1 64215
Affinity Capture-MS Homo sapiens
44 BMP10  
Two-hybrid Homo sapiens
45 NAT8  
Two-hybrid Homo sapiens
46 CD63 967
Affinity Capture-MS Homo sapiens
47 ALG11  
Affinity Capture-MS Homo sapiens
48 ATP8  
Affinity Capture-MS Homo sapiens
49 LAPTM4A 9741
Affinity Capture-MS Homo sapiens
50 MTCH2 23788
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSPAN31 is involved
No pathways found





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