Gene description for LAPTM4A
Gene name lysosomal protein transmembrane 4 alpha
Gene symbol LAPTM4A
Other names/aliases HUMORF13
LAPTM4
MBNT
Mtrp
Species Homo sapiens
 Database cross references - LAPTM4A
ExoCarta ExoCarta_9741
Vesiclepedia VP_9741
Entrez Gene 9741
HGNC 6924
UniProt Q15012  
 LAPTM4A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LAPTM4A
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 IDA
    Golgi apparatus GO:0005794 IDA
    late endosome membrane GO:0031902 IDA
 Experiment description of studies that identified LAPTM4A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LAPTM4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UNK  
Affinity Capture-RNA Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 TFRC 7037
Affinity Capture-Western Homo sapiens
4 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SUN3  
Affinity Capture-MS Homo sapiens
6 UGT1A5  
Affinity Capture-MS Homo sapiens
7 HNRNPU 3192
Co-fractionation Homo sapiens
8 WWP2 11060
Affinity Capture-MS Homo sapiens
9 MTNR1A  
Two-hybrid Homo sapiens
10 IGF2BP3 10643
Co-fractionation Homo sapiens
11 TSPAN31 6302
Affinity Capture-MS Homo sapiens
12 TUBB3 10381
Two-hybrid Homo sapiens
13 NEDD4 4734
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 TRIM55  
Two-hybrid Homo sapiens
16 DLK1  
Affinity Capture-MS Homo sapiens
17 C16orf58 64755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TRIM63  
Two-hybrid Homo sapiens
19 HCST  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LAPTM4A is involved
No pathways found





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