Gene description for ELOVL1
Gene name ELOVL fatty acid elongase 1
Gene symbol ELOVL1
Other names/aliases CGI-88
Ssc1
Species Homo sapiens
 Database cross references - ELOVL1
ExoCarta ExoCarta_64834
Vesiclepedia VP_64834
Entrez Gene 64834
HGNC 14418
MIM 611813
UniProt Q9BW60  
 ELOVL1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ELOVL1
Molecular Function
    protein binding GO:0005515 IPI
    fatty acid elongase activity GO:0009922 EXP
    fatty acid elongase activity GO:0009922 IBA
    fatty acid elongase activity GO:0009922 IDA
Biological Process
    unsaturated fatty acid biosynthetic process GO:0006636 IEA
    fatty acid elongation, saturated fatty acid GO:0019367 IBA
    fatty acid elongation, saturated fatty acid GO:0019367 IDA
    sphingolipid biosynthetic process GO:0030148 IBA
    sphingolipid biosynthetic process GO:0030148 IMP
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IBA
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IDA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IBA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    alpha-linolenic acid metabolic process GO:0036109 TAS
    very long-chain fatty acid biosynthetic process GO:0042761 IBA
    very long-chain fatty acid biosynthetic process GO:0042761 IDA
    linoleic acid metabolic process GO:0043651 TAS
    ceramide biosynthetic process GO:0046513 IEA
    establishment of skin barrier GO:0061436 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 NAS
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified ELOVL1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ELOVL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLPP 8192
Proximity Label-MS Homo sapiens
2 UBE3B 89910
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 VIPR2  
Affinity Capture-MS Homo sapiens
5 TWF2 11344
Affinity Capture-MS Homo sapiens
6 ANP32A 8125
Affinity Capture-MS Homo sapiens
7 CANX 821
Affinity Capture-MS Homo sapiens
8 TP53 7157
Affinity Capture-MS Homo sapiens
9 RAB5A 5868
Affinity Capture-MS Homo sapiens
10 LDHA 3939
Affinity Capture-MS Homo sapiens
11 RAB11B 9230
Affinity Capture-MS Homo sapiens
12 GLP1R  
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
13 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
14 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
15 DCTN2 10540
Affinity Capture-MS Homo sapiens
16 ZC3HC1  
Affinity Capture-MS Homo sapiens
17 PSMD10 5716
Affinity Capture-MS Homo sapiens
18 DDX58 23586
Affinity Capture-RNA Homo sapiens
19 HSD17B12 51144
Affinity Capture-Western Homo sapiens
20 SOX2  
Affinity Capture-MS Homo sapiens
21 NXF1 10482
Affinity Capture-RNA Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 CERS2 29956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 DHFR 1719
Affinity Capture-MS Homo sapiens
25 MOV10 4343
Affinity Capture-RNA Homo sapiens
26 TAGLN2 8407
Affinity Capture-MS Homo sapiens
27 RPA3 6119
Proximity Label-MS Homo sapiens
28 Tubg1 103733
Affinity Capture-MS Mus musculus
29 HPRT1 3251
Affinity Capture-MS Homo sapiens
30 VDAC1 7416
Affinity Capture-MS Homo sapiens
31 HTR1B  
Affinity Capture-MS Homo sapiens
32 TECR 9524
Affinity Capture-Western Homo sapiens
33 SLC1A1 6505
Affinity Capture-MS Homo sapiens
34 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
35 ATP2A3 489
Affinity Capture-MS Homo sapiens
36 Smn1 20595
Affinity Capture-MS Mus musculus
37 RAE1 8480
Affinity Capture-MS Homo sapiens
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