Gene description for SLC15A2
Gene name solute carrier family 15 (oligopeptide transporter), member 2
Gene symbol SLC15A2
Other names/aliases PEPT2
Species Homo sapiens
 Database cross references - SLC15A2
ExoCarta ExoCarta_6565
Vesiclepedia VP_6565
Entrez Gene 6565
HGNC 10921
MIM 602339
UniProt Q16348  
 SLC15A2 identified in sEVs derived from the following tissue/cell type
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for SLC15A2
Molecular Function
    protein binding GO:0005515 IPI
    peptide:proton symporter activity GO:0015333 IDA
    peptide:proton symporter activity GO:0015333 TAS
    tripeptide transmembrane transporter activity GO:0042937 ISS
    dipeptide transmembrane transporter activity GO:0071916 IBA
    dipeptide transmembrane transporter activity GO:0071916 IDA
Biological Process
    monoatomic ion transport GO:0006811 TAS
    protein transport GO:0015031 IEA
    peptidoglycan transport GO:0015835 ISS
    xenobiotic transport GO:0042908 ISS
    dipeptide transport GO:0042938 ISS
    renal absorption GO:0070293 ISS
    regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0070424 ISS
    dipeptide import across plasma membrane GO:0140206 IBA
    dipeptide import across plasma membrane GO:0140206 IDA
    tripeptide import across plasma membrane GO:0140207 ISS
    antibacterial innate immune response GO:0140367 IDA
    transport across blood-brain barrier GO:0150104 NAS
    proton transmembrane transport GO:1902600 IEA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 RCA
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 ISS
    phagocytic vesicle membrane GO:0030670 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC15A2 in sEVs
1
Experiment ID 622
MISEV standards
EM
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 623
MISEV standards
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with IPMN with microinvasive cancer (IPMNca)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
4
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC15A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ENKD1  
Two-hybrid Homo sapiens
2 KRTAP12-3  
Two-hybrid Homo sapiens
3 LMO4  
Two-hybrid Homo sapiens
4 WWOX 51741
Two-hybrid Homo sapiens
5 ADAM12 8038
Two-hybrid Homo sapiens
6 VENTX  
Two-hybrid Homo sapiens
7 SMARCC1 6599
Two-hybrid Homo sapiens
8 KLHL38  
Two-hybrid Homo sapiens
9 KRT34  
Two-hybrid Homo sapiens
10 PLSCR4  
Two-hybrid Homo sapiens
11 KRTAP15-1  
Two-hybrid Homo sapiens
12 FAM46B  
Two-hybrid Homo sapiens
13 TLX3  
Two-hybrid Homo sapiens
14 OTX1  
Two-hybrid Homo sapiens
15 C12orf49  
Negative Genetic Homo sapiens
16 KRTAP26-1  
Two-hybrid Homo sapiens
17 C11orf87  
Two-hybrid Homo sapiens
18 WDYHV1  
Two-hybrid Homo sapiens
19 UQCRH 7388
Co-fractionation Homo sapiens
20 AQP1 358
Two-hybrid Homo sapiens
21 KRTAP6-3  
Two-hybrid Homo sapiens
22 KPRP 448834
Two-hybrid Homo sapiens
23 KRTAP12-2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SLC15A2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here