Gene description for MTMR9
Gene name myotubularin related protein 9
Gene symbol MTMR9
Other names/aliases C8orf9
LIP-STYX
MTMR8
Species Homo sapiens
 Database cross references - MTMR9
ExoCarta ExoCarta_66036
Vesiclepedia VP_66036
Entrez Gene 66036
HGNC 14596
MIM 606260
UniProt Q96QG7  
 MTMR9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTMR9
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase binding GO:0019903 IBA
    protein phosphatase binding GO:0019903 IPI
    enzyme regulator activity GO:0030234 IEA
Biological Process
    endocytosis GO:0006897 IEA
    negative regulation of autophagy GO:0010507 IBA
    negative regulation of autophagy GO:0010507 IPI
    positive regulation of phosphatase activity GO:0010922 IDA
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    protein stabilization GO:0050821 IDA
    regulation of phosphatidylinositol dephosphorylation GO:0060304 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 TAS
    ruffle membrane GO:0032587 IEA
    protein-containing complex GO:0032991 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified MTMR9 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTMR9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTSE  
Affinity Capture-MS Homo sapiens
2 AATK  
Two-hybrid Homo sapiens
3 KRT27 342574
Two-hybrid Homo sapiens
4 NECAB2  
Two-hybrid Homo sapiens
5 EBAG9 9166
Proximity Label-MS Homo sapiens
6 MADD 8567
Affinity Capture-MS Homo sapiens
7 MEI4  
Two-hybrid Homo sapiens
8 NMI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 CDA 978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 VAC14 55697
Two-hybrid Homo sapiens
12 ATG9A 79065
Proximity Label-MS Homo sapiens
13 TTR 7276
Affinity Capture-MS Homo sapiens
14 MID1IP1  
Affinity Capture-MS Homo sapiens
15 SPG21 51324
Two-hybrid Homo sapiens
16 MTMR8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
17 FAM218A  
Affinity Capture-MS Homo sapiens
18 WDR45B 56270
Affinity Capture-MS Homo sapiens
19 CUL3 8452
Affinity Capture-MS Homo sapiens
20 ERBB4 2066
Two-hybrid Homo sapiens
21 CENPF 1063
Affinity Capture-MS Homo sapiens
22 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
23 MOS 4342
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 CLU 1191
Affinity Capture-MS Homo sapiens
25 ERBB3 2065
Two-hybrid Homo sapiens
26 TMEM159 57146
Affinity Capture-MS Homo sapiens
27 EMP3 2014
Affinity Capture-MS Homo sapiens
28 KIAA1328  
Two-hybrid Homo sapiens
29 MTMR9 66036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
30 APOD 347
Affinity Capture-MS Homo sapiens
31 ROR2 4920
Two-hybrid Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 C12orf49  
Negative Genetic Homo sapiens
34 KDM1A 23028
Two-hybrid Homo sapiens
35 EMILIN1 11117
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 MTMR7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
37 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
38 ATPIF1 93974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ACTN3 89
Affinity Capture-MS Homo sapiens
40 ZNF655  
Two-hybrid Homo sapiens
41 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MTMR1 8776
Affinity Capture-MS Homo sapiens
43 BICD2 23299
Proximity Label-MS Homo sapiens
44 FAM169A  
Two-hybrid Homo sapiens
45 MTMR2 8898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 EWSR1 2130
Two-hybrid Homo sapiens
47 INCA1  
Two-hybrid Homo sapiens
48 ZC3H3  
Affinity Capture-MS Homo sapiens
49 DSP 1832
Affinity Capture-MS Homo sapiens
50 LNX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
51 DDX55  
Affinity Capture-MS Homo sapiens
52 PTK7 5754
Two-hybrid Homo sapiens
53 MTMR6 9107
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
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