Gene description for Nek10
Gene name NIMA (never in mitosis gene a)- related kinase 10
Gene symbol Nek10
Other names/aliases Gm282
Species Mus musculus
 Database cross references - Nek10
ExoCarta ExoCarta_674895
Vesiclepedia VP_674895
Entrez Gene 674895
UniProt Q3UGM2  
 Nek10 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Nek10
Molecular Function
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    metal ion binding GO:0046872 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 ISO
    positive regulation of protein autophosphorylation GO:0031954 ISO
    positive regulation of MAP kinase activity GO:0043406 ISO
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    mucociliary clearance GO:0120197 ISO
    mucociliary clearance GO:0120197 ISS
    regulation of cell cycle G2/M phase transition GO:1902749 IBA
    regulation of cell cycle G2/M phase transition GO:1902749 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    protein kinase complex GO:1902911 ISO
 Experiment description of studies that identified Nek10 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nek10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Map2k1 26395
Affinity Capture-Western Mus musculus
2 Raf1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Nek10 is involved
No pathways found





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