Gene description for TCN1
Gene name transcobalamin I (vitamin B12 binding protein, R binder family)
Gene symbol TCN1
Other names/aliases HC
TC-1
TC1
TCI
Species Homo sapiens
 Database cross references - TCN1
ExoCarta ExoCarta_6947
Vesiclepedia VP_6947
Entrez Gene 6947
HGNC 11652
MIM 189905
UniProt P20061  
 TCN1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TCN1
Molecular Function
    protein binding GO:0005515 IPI
    cobalamin binding GO:0031419 IBA
    molecular sequestering activity GO:0140313 EXP
    cargo receptor ligand activity GO:0140355 EXP
Biological Process
    cobalt ion transport GO:0006824 IEA
    cobalamin transport GO:0015889 IBA
    cobalamin transport GO:0015889 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    specific granule lumen GO:0035580 TAS
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified TCN1 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TCN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ikbip  
Affinity Capture-MS Mus musculus
2 FNDC5  
Affinity Capture-MS Homo sapiens
3 ITLN2  
Affinity Capture-MS Homo sapiens
4 CBL 867
Reconstituted Complex Homo sapiens
5 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GNG8  
Affinity Capture-MS Homo sapiens
7 TIMM10  
Affinity Capture-MS Homo sapiens
8 SFXN4  
Affinity Capture-MS Homo sapiens
9 EBF2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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