Gene description for CBL
Gene name	Cbl proto-oncogene, E3 ubiquitin protein ligase
Gene symbol	CBL
Other names/aliases	C-CBL CBL2 FRA11B NSLL RNF55
Species	Homo sapiens
Database cross references - CBL
ExoCarta	ExoCarta_867
Vesiclepedia	VP_867
Entrez Gene	867
HGNC	1541
MIM	165360
UniProt	P22681
CBL identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Endothelial cells	26027894
Neuroblastoma cells	25944692

Gene ontology annotations for CBL

Molecular Function     phosphotyrosine residue binding GO:0001784 IEA     ubiquitin-protein transferase activity GO:0004842 TAS     calcium ion binding GO:0005509 IEA     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IPI     receptor tyrosine kinase binding GO:0030971 IBA     phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IEA     cadherin binding GO:0045296 HDA     ephrin receptor binding GO:0046875 IPI     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 TAS Biological Process     protein polyubiquitination GO:0000209 IEA     ubiquitin-dependent protein catabolic process GO:0006511 IMP     protein monoubiquitination GO:0006513 IEA     DNA damage response GO:0006974 IEA     signal transduction GO:0007165 IBA     male gonad development GO:0008584 IEA     response to gamma radiation GO:0010332 IEA     response to activity GO:0014823 IEA     protein ubiquitination GO:0016567 IDA     protein ubiquitination GO:0016567 IMP     protein ubiquitination GO:0016567 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     regulation of Rap protein signal transduction GO:0032487 IEA     response to testosterone GO:0033574 IEA     cellular response to platelet-derived growth factor stimulus GO:0036120 IEA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IBA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IMP     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS     response to starvation GO:0042594 IEA     negative regulation of apoptotic process GO:0043066 IMP     mast cell degranulation GO:0043303 IEA     response to ethanol GO:0045471 IEA     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 TAS     symbiont entry into host cell GO:0046718 TAS     positive regulation of receptor-mediated endocytosis GO:0048260 IMP     protein autoubiquitination GO:0051865 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     ubiquitin-dependent endocytosis GO:0070086 IEA     cellular response to hypoxia GO:0071456 IEA     cellular response to nerve growth factor stimulus GO:1990090 IEA     regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000583 ISS Subcellular Localization     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     focal adhesion GO:0005925 IEA     cilium GO:0005929 IDA     flotillin complex GO:0016600 ISS     growth cone GO:0030426 IEA     membrane raft GO:0045121 IBA     perinuclear region of cytoplasm GO:0048471 IEA