Gene description for BLK
Gene name BLK proto-oncogene, Src family tyrosine kinase
Gene symbol BLK
Other names/aliases MODY11
Species Homo sapiens
 Database cross references - BLK
ExoCarta ExoCarta_640
Vesiclepedia VP_640
Entrez Gene 640
HGNC 1057
MIM 191305
UniProt P51451  
 BLK identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BLK
Molecular Function
    protein tyrosine kinase activity GO:0004713 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IMP
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    cell differentiation GO:0030154 IBA
    positive regulation of insulin secretion GO:0032024 IMP
    positive regulation of protein binding GO:0032092 IMP
    intracellular signal transduction GO:0035556 TAS
    B cell receptor signaling pathway GO:0050853 IDA
    B cell receptor signaling pathway GO:0050853 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified BLK in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BLK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDELR3 11015
Affinity Capture-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 ATPIF1 93974
Affinity Capture-MS Homo sapiens
4 MBTD1  
Affinity Capture-MS Homo sapiens
5 YTHDF1 54915
Affinity Capture-MS Homo sapiens
6 CDC45  
Affinity Capture-MS Homo sapiens
7 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
8 NFATC1 4772
Affinity Capture-MS Homo sapiens
9 RPL37A 6168
Affinity Capture-MS Homo sapiens
10 ANKRD9  
Affinity Capture-MS Homo sapiens
11 UBE3A 7337
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 SOCS1  
Biochemical Activity Homo sapiens
13 DNAJC25 548645
Affinity Capture-MS Homo sapiens
14 GRB10 2887
Two-hybrid Homo sapiens
15 CD79A  
Affinity Capture-Western Homo sapiens
16 GNGT1  
Affinity Capture-MS Homo sapiens
17 STAP2 55620
Two-hybrid Homo sapiens
18 SLC30A4 7782
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MTRF1  
Affinity Capture-MS Homo sapiens
20 ATP5L 10632
Affinity Capture-MS Homo sapiens
21 SYCP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ZBTB8A  
Two-hybrid Homo sapiens
23 GNG12 55970
Affinity Capture-MS Homo sapiens
24 ATP5D 513
Affinity Capture-MS Homo sapiens
25 PLCG2 5336
Reconstituted Complex Homo sapiens
26 JAKMIP1 152789
Two-hybrid Homo sapiens
27 ZMAT1  
Two-hybrid Homo sapiens
28 Nedd4 25489
Biochemical Activity Rattus norvegicus
29 TLR3  
Affinity Capture-MS Homo sapiens
30 APOC3 345
Affinity Capture-MS Homo sapiens
31 SENP1  
Affinity Capture-MS Homo sapiens
32 FBXO17 115290
Affinity Capture-MS Homo sapiens
33 STAT3 6774
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 TDP2 51567
Two-hybrid Homo sapiens
35 CDH16  
Affinity Capture-MS Homo sapiens
36 CHIT1  
Affinity Capture-MS Homo sapiens
37 HSP90B1 7184
Affinity Capture-MS Homo sapiens
38 ATP5O 539
Affinity Capture-MS Homo sapiens
39 USMG5 84833
Affinity Capture-MS Homo sapiens
40 TULP3 7289
Affinity Capture-MS Homo sapiens
41 Mbp 17196
Protein-peptide Mus musculus
42 ATP5H 10476
Affinity Capture-MS Homo sapiens
43 SSBP3  
Two-hybrid Homo sapiens
44 SOCS3 9021
Two-hybrid Homo sapiens
45 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
46 NCSTN 23385
Affinity Capture-MS Homo sapiens
47 CINP  
Affinity Capture-MS Homo sapiens
48 Bcas2  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
49 CCL15  
Affinity Capture-MS Homo sapiens
50 CDKN2AIP  
Affinity Capture-MS Homo sapiens
51 KIT 3815
Reconstituted Complex Homo sapiens
52 RNF4 6047
Affinity Capture-MS Homo sapiens
53 TGM2 7052
Affinity Capture-MS Homo sapiens
54 C3orf62  
Affinity Capture-MS Homo sapiens
55 ERBB3 2065
Reconstituted Complex Homo sapiens
56 OR5C1  
Affinity Capture-MS Homo sapiens
57 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 CBL 867
Affinity Capture-Western Homo sapiens
59 SCGB1A1  
Affinity Capture-MS Homo sapiens
60 EEF1E1 9521
Affinity Capture-MS Homo sapiens
61 ARL5B  
Affinity Capture-MS Homo sapiens
62 MYH9 4627
Affinity Capture-MS Homo sapiens
63 FBXL22  
Affinity Capture-MS Homo sapiens
64 SNRPD1 6632
Affinity Capture-MS Homo sapiens
65 BCL2L1 598
Reconstituted Complex Homo sapiens
66 PIK3R1 5295
Two-hybrid Homo sapiens
67 LRTM2  
Affinity Capture-MS Homo sapiens
68 CDX1  
Affinity Capture-MS Homo sapiens
69 LRRTM4  
Affinity Capture-MS Homo sapiens
70 ATP5B 506
Affinity Capture-MS Homo sapiens
71 CAMK1 8536
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 MET 4233
Reconstituted Complex Homo sapiens
73 SPATA22  
Affinity Capture-MS Homo sapiens
74 BIRC2  
Two-hybrid Homo sapiens
75 CXCR4 7852
Affinity Capture-MS Homo sapiens
76 ATP6V0D2 245972
Affinity Capture-MS Homo sapiens
77 SLA  
Two-hybrid Homo sapiens
78 ATP5I 521
Affinity Capture-MS Homo sapiens
79 CD79B 974
Affinity Capture-Western Homo sapiens
80 PIGP  
Affinity Capture-MS Homo sapiens
81 IKZF3  
Two-hybrid Homo sapiens
82 SH2D1B  
Two-hybrid Homo sapiens
83 EEF2 1938
Affinity Capture-MS Homo sapiens
84 PARP12 64761
Affinity Capture-MS Homo sapiens
85 ATP5F1 515
Affinity Capture-MS Homo sapiens
86 ERBB4 2066
Reconstituted Complex Homo sapiens
87 EFS  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 EGFR 1956
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
89 EFCAB11  
Affinity Capture-MS Homo sapiens
90 CNKSR3 154043
Affinity Capture-MS Homo sapiens
91 TRAF3 7187
Affinity Capture-Western Homo sapiens
92 GAB1  
Reconstituted Complex Homo sapiens
93 ATP5J2 9551
Affinity Capture-MS Homo sapiens
94 ZMYM6  
Affinity Capture-MS Homo sapiens
95 FXR2 9513
Two-hybrid Homo sapiens
96 ATP5E 514
Affinity Capture-MS Homo sapiens
97 A4GNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 TLR2 7097
Affinity Capture-MS Homo sapiens
99 BBX 56987
Affinity Capture-MS Homo sapiens
100 FAM217B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 TSR1 55720
Affinity Capture-MS Homo sapiens
102 AVPR2  
Affinity Capture-MS Homo sapiens
103 AP3S1 1176
Affinity Capture-MS Homo sapiens
104 KCNE1  
Affinity Capture-MS Homo sapiens
105 RNASE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ATP5J 522
Affinity Capture-MS Homo sapiens
107 PHB2 11331
Affinity Capture-MS Homo sapiens
108 GLRA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 USP25  
Affinity Capture-MS Homo sapiens
110 ATP5A1 498
Affinity Capture-MS Homo sapiens
111 ABCA9 10350
Affinity Capture-MS Homo sapiens
112 C15orf53  
Affinity Capture-MS Homo sapiens
113 FXR1 8087
Two-hybrid Homo sapiens
114 CTAG1B  
Affinity Capture-MS Homo sapiens
115 GAD1  
Affinity Capture-MS Homo sapiens
116 ZNF774  
Two-hybrid Homo sapiens
117 ANKRD54  
Affinity Capture-MS Homo sapiens
118 APBB3  
Affinity Capture-MS Homo sapiens
119 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
120 RTN1 6252
Affinity Capture-MS Homo sapiens
121 EDEM2  
Affinity Capture-MS Homo sapiens
122 SUGP2  
Affinity Capture-MS Homo sapiens
123 GAPDH 2597
Affinity Capture-MS Homo sapiens
124 BCL2  
Reconstituted Complex Homo sapiens
125 YBX3 8531
Affinity Capture-MS Homo sapiens
126 GLYR1 84656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 ATP5C1 509
Affinity Capture-MS Homo sapiens
128 CTNND1 1500
Affinity Capture-MS Homo sapiens
129 AR 367
Reconstituted Complex Homo sapiens
130 CCDC96  
Affinity Capture-MS Homo sapiens
131 ZBTB42  
Two-hybrid Homo sapiens
132 HSF2BP  
Two-hybrid Homo sapiens
133 ALS2CR12  
Two-hybrid Homo sapiens
134 CYTIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 SLC2A13 114134
Affinity Capture-MS Homo sapiens
136 CXCL16 58191
Affinity Capture-MS Homo sapiens
137 TAGAP  
Affinity Capture-MS Homo sapiens
138 PIK3R3 8503
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here