Gene description for PTK2B
Gene name	protein tyrosine kinase 2 beta
Gene symbol	PTK2B
Other names/aliases	CADTK CAKB FADK2 FAK2 PKB PTK PYK2 RAFTK
Species	Homo sapiens
Database cross references - PTK2B
ExoCarta	ExoCarta_2185
Vesiclepedia	VP_2185
Entrez Gene	2185
HGNC	9612
MIM	601212
UniProt	Q14289
PTK2B identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for PTK2B

Molecular Function     calcium/calmodulin-dependent protein kinase activity GO:0004683 ISS     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     non-membrane spanning protein tyrosine kinase activity GO:0004715 ISS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ubiquitin protein ligase binding GO:0031625 IEA     glutamate receptor binding GO:0035254 IEA     histone H3Y41 kinase activity GO:0035401 IEA     3-phosphoinositide-dependent protein kinase binding GO:0043423 IEA     protein-containing complex binding GO:0044877 IEA     neurotransmitter receptor regulator activity GO:0099602 ISS     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     MAPK cascade GO:0000165 IEA     oocyte maturation GO:0001556 IEA     response to hypoxia GO:0001666 IEA     positive regulation of cell-matrix adhesion GO:0001954 IMP     sprouting angiogenesis GO:0002040 ISS     adaptive immune response GO:0002250 IEA     marginal zone B cell differentiation GO:0002315 ISS     response to ischemia GO:0002931 IEA     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     apoptotic process GO:0006915 TAS     cellular defense response GO:0006968 ISS     signal transduction GO:0007165 TAS     cell surface receptor signaling pathway GO:0007166 IMP     signal complex assembly GO:0007172 IEA     epidermal growth factor receptor signaling pathway GO:0007173 IBA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     integrin-mediated signaling pathway GO:0007229 IMP     positive regulation of cell population proliferation GO:0008284 IMP     negative regulation of cell population proliferation GO:0008285 IMP     regulation of cell shape GO:0008360 IMP     response to xenobiotic stimulus GO:0009410 IEA     response to mechanical stimulus GO:0009612 IEA     response to hormone GO:0009725 IEA     response to glucose GO:0009749 IEA     positive regulation of endothelial cell migration GO:0010595 IDA     negative regulation of muscle cell apoptotic process GO:0010656 IEA     regulation of macrophage chemotaxis GO:0010758 ISS     positive regulation of neuron projection development GO:0010976 IMP     glial cell proliferation GO:0014009 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     regulation of cell adhesion GO:0030155 IBA     regulation of cell adhesion GO:0030155 IMP     positive regulation of cell growth GO:0030307 IEA     positive regulation of cell migration GO:0030335 IBA     positive regulation of cell migration GO:0030335 IMP     negative regulation of bone mineralization GO:0030502 ISS     positive regulation of actin filament polymerization GO:0030838 IMP     cortical cytoskeleton organization GO:0030865 ISS     neuron projection development GO:0031175 IEA     regulation of actin cytoskeleton organization GO:0032956 ISS     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     response to immobilization stress GO:0035902 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 IDA     response to cocaine GO:0042220 IEA     response to hydrogen peroxide GO:0042542 IEA     activation of Janus kinase activity GO:0042976 IMP     negative regulation of apoptotic process GO:0043066 IMP     stress fiber assembly GO:0043149 IEA     response to cation stress GO:0043157 IEA     negative regulation of potassium ion transport GO:0043267 IDA     negative regulation of neuron apoptotic process GO:0043524 ISS     blood vessel endothelial cell migration GO:0043534 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     bone resorption GO:0045453 ISS     response to ethanol GO:0045471 IEA     negative regulation of myeloid cell differentiation GO:0045638 IMP     positive regulation of translation GO:0045727 IEA     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of protein kinase activity GO:0045860 IMP     positive regulation of JNK cascade GO:0046330 IMP     protein autophosphorylation GO:0046777 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 IMP     focal adhesion assembly GO:0048041 IEA     regulation of synaptic plasticity GO:0048167 TAS     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISS     response to cAMP GO:0051591 IEA     response to calcium ion GO:0051592 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS     long-term synaptic potentiation GO:0060291 ISS     long-term synaptic depression GO:0060292 IEA     protein-containing complex assembly GO:0065003 TAS     chemokine-mediated signaling pathway GO:0070098 ISS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     cellular response to retinoic acid GO:0071300 IMP     cellular response to fluid shear stress GO:0071498 IEA     endothelin receptor signaling pathway GO:0086100 IMP     regulation of postsynaptic density assembly GO:0099151 IEA     postsynaptic modulation of chemical synaptic transmission GO:0099170 IEA     regulation of ubiquitin-dependent protein catabolic process GO:2000058 IDA     positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA     positive regulation of excitatory postsynaptic potential GO:2000463 ISS     positive regulation of B cell chemotaxis GO:2000538 ISS     positive regulation of DNA biosynthetic process GO:2000573 IEA Subcellular Localization     nucleus GO:0005634 IDA     cytoplasm GO:0005737 TAS     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IBA     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 IDA     cell cortex GO:0005938 IEA     postsynaptic density GO:0014069 ISS     postsynaptic density GO:0014069 TAS     NMDA selective glutamate receptor complex GO:0017146 ISS     lamellipodium GO:0030027 IDA     dendrite GO:0030425 ISS     growth cone GO:0030426 ISS     neuronal cell body GO:0043025 ISS     dendritic spine GO:0043197 IBA     cell body GO:0044297 ISS     perinuclear region of cytoplasm GO:0048471 IDA     apical dendrite GO:0097440 ISS     Schaffer collateral - CA1 synapse GO:0098685 IEA     presynapse GO:0098793 IEA     glutamatergic synapse GO:0098978 IEA     postsynaptic density, intracellular component GO:0099092 IEA