Gene description for GP6
Gene name glycoprotein VI (platelet)
Gene symbol GP6
Other names/aliases BDPLT11
GPIV
GPVI
Species Homo sapiens
 Database cross references - GP6
ExoCarta ExoCarta_51206
Vesiclepedia VP_51206
Entrez Gene 51206
HGNC 14388
MIM 605546
UniProt Q9HCN6  
 GP6 identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GP6
Molecular Function
    transmembrane signaling receptor activity GO:0004888 TAS
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 TAS
    signaling receptor activity GO:0038023 TAS
    collagen receptor activity GO:0038064 IEA
    protein tyrosine kinase binding GO:1990782 IPI
Biological Process
    immune response-regulating signaling pathway GO:0002764 IBA
    enzyme-linked receptor protein signaling pathway GO:0007167 TAS
    platelet activation GO:0030168 NAS
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    collagen-activated signaling pathway GO:0038065 TAS
    platelet aggregation GO:0070527 IEA
    positive regulation of platelet aggregation GO:1901731 TAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 HDA
    membrane raft GO:0045121 IDA
    extracellular exosome GO:0070062 HDA
    tetraspanin-enriched microdomain GO:0097197 IDA
 Experiment description of studies that identified GP6 in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 APEX1 328
Affinity Capture-RNA Homo sapiens
3 FCER1G 2207
Affinity Capture-Western Homo sapiens
4 FYN 2534
Reconstituted Complex Homo sapiens
5 CALM1 801
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 TGFB1I1 7041
Affinity Capture-Western Homo sapiens
7 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 PTK2B 2185
Affinity Capture-Western Homo sapiens
9 NCF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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