Gene description for FCER1G
Gene name Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Gene symbol FCER1G
Other names/aliases FCRG
Species Homo sapiens
 Database cross references - FCER1G
ExoCarta ExoCarta_2207
Vesiclepedia VP_2207
Entrez Gene 2207
HGNC 3611
MIM 147139
UniProt P30273  
 FCER1G identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for FCER1G
Molecular Function
    protein binding GO:0005515 IPI
    IgE receptor activity GO:0019767 IBA
    IgE binding GO:0019863 IEA
    IgG binding GO:0019864 IBA
    identical protein binding GO:0042802 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    neutrophil activation involved in immune response GO:0002283 IBA
    T cell differentiation involved in immune response GO:0002292 IBA
    Fc receptor mediated stimulatory signaling pathway GO:0002431 IBA
    regulation of platelet activation GO:0010543 IBA
    immunoglobulin mediated immune response GO:0016064 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    neutrophil chemotaxis GO:0030593 IBA
    receptor internalization GO:0031623 ISS
    positive regulation of interleukin-4 production GO:0032753 ISS
    Fc-gamma receptor signaling pathway GO:0038094 IBA
    Fc-epsilon receptor signaling pathway GO:0038095 IMP
    interleukin-3-mediated signaling pathway GO:0038156 ISS
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IBA
    defense response to bacterium GO:0042742 IBA
    innate immune response GO:0045087 IBA
    positive regulation of phagocytosis GO:0050766 IBA
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IDA
    Fc-epsilon receptor I complex GO:0032998 IBA
    Fc-gamma receptor III complex GO:0033001 IDA
    tertiary granule membrane GO:0070821 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified FCER1G in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FCER1G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDIPT 10423
Two-hybrid Homo sapiens
2 SEC22B 9554
Two-hybrid Homo sapiens
3 C2CD2L 9854
Two-hybrid Homo sapiens
4 EBP  
Two-hybrid Homo sapiens
5 UNC50  
Two-hybrid Homo sapiens
6 SLC30A8  
Two-hybrid Homo sapiens
7 KCNA1  
Two-hybrid Homo sapiens
8 TMEM107 84314
Two-hybrid Homo sapiens
9 PEX16 9409
Two-hybrid Homo sapiens
10 NCR1  
Two-hybrid Homo sapiens
11 LEPROTL1 23484
Two-hybrid Homo sapiens
12 GJA5 2702
Two-hybrid Homo sapiens
13 FCER1A  
Affinity Capture-Western Homo sapiens
14 FFAR2  
Two-hybrid Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
16 GP6 51206
Affinity Capture-Western Homo sapiens
17 SLC35G2  
Two-hybrid Homo sapiens
18 FA2H  
Two-hybrid Homo sapiens
19 THBD 7056
Two-hybrid Homo sapiens
20 SLC10A1  
Two-hybrid Homo sapiens
21 SMIM1 388588
Two-hybrid Homo sapiens
22 EMR2  
Two-hybrid Homo sapiens
23 IER3IP1 51124
Two-hybrid Homo sapiens
24 TMEM120B  
Two-hybrid Homo sapiens
25 TMEM19  
Two-hybrid Homo sapiens
26 TMEM14B  
Two-hybrid Homo sapiens
27 MS4A2  
Affinity Capture-Western Homo sapiens
28 FXYD6  
Two-hybrid Homo sapiens
29 NRM 11270
Two-hybrid Homo sapiens
30 LNPEP 4012
Two-hybrid Homo sapiens
31 KCNN3  
Two-hybrid Homo sapiens
32 FUNDC2 65991
Two-hybrid Homo sapiens
33 NCR3  
Two-hybrid Homo sapiens
34 SFXN3 81855
Two-hybrid Homo sapiens
35 SLC38A7 55238
Two-hybrid Homo sapiens
36 CYP4F2  
Two-hybrid Homo sapiens
37 MFF 56947
Two-hybrid Homo sapiens
38 COX20  
Two-hybrid Homo sapiens
39 SFXN1 94081
Two-hybrid Homo sapiens
40 TSPO2  
Two-hybrid Homo sapiens
41 TMEM179B 374395
Two-hybrid Homo sapiens
42 FAM209A 200232
Two-hybrid Homo sapiens
43 PEMT  
Two-hybrid Homo sapiens
44 SLC39A2  
Two-hybrid Homo sapiens
45 USP13  
Affinity Capture-Western Homo sapiens
46 GIMAP5  
Two-hybrid Homo sapiens
47 YIF1A 10897
Two-hybrid Homo sapiens
48 C16orf58 64755
Two-hybrid Homo sapiens
49 SYNJ2BP 55333
Two-hybrid Homo sapiens
50 UBE2J1 51465
Two-hybrid Homo sapiens
51 TMEM218  
Two-hybrid Homo sapiens
52 USP5 8078
Affinity Capture-Western Homo sapiens
53 SLC13A4  
Two-hybrid Homo sapiens
54 UNC93A  
Two-hybrid Homo sapiens
55 YIPF4 84272
Two-hybrid Homo sapiens
56 FCAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 GPR61  
Two-hybrid Homo sapiens
58 VAMP1 6843
Two-hybrid Homo sapiens
59 PDZK1IP1 10158
Two-hybrid Homo sapiens
60 PLP2 5355
Two-hybrid Homo sapiens
61 SYS1  
Two-hybrid Homo sapiens
62 TMEM31  
Two-hybrid Homo sapiens
63 SYK 6850
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
64 SLC1A1 6505
Two-hybrid Homo sapiens
65 DGAT2L6  
Two-hybrid Homo sapiens
66 FAXDC2  
Two-hybrid Homo sapiens
67 CLEC4E  
Two-hybrid Homo sapiens
68 UBIAD1 29914
Two-hybrid Homo sapiens
69 YIPF6 286451
Two-hybrid Homo sapiens
70 TPRG1  
Two-hybrid Homo sapiens
71 TMEM140  
Two-hybrid Homo sapiens
72 SLC7A1 6541
Two-hybrid Homo sapiens
73 ORMDL2 29095
Two-hybrid Homo sapiens
74 STX12 23673
Two-hybrid Homo sapiens
View the network image/svg+xml



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