Gene description for CDIPT
Gene name CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene symbol CDIPT
Other names/aliases PIS
PIS1
Species Homo sapiens
 Database cross references - CDIPT
ExoCarta ExoCarta_10423
Vesiclepedia VP_10423
Entrez Gene 10423
HGNC 1769
MIM 605893
UniProt O14735  
 CDIPT identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CDIPT
Molecular Function
    CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity GO:0003881 IBA
    CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity GO:0003881 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 IBA
    phosphatidylinositol biosynthetic process GO:0006661 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi apparatus GO:0005794 IBA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified CDIPT in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CDIPT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 GPR151  
Two-hybrid Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 UBL4A 8266
Affinity Capture-MS Homo sapiens
7 COIL  
Proximity Label-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 YTHDF1 54915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPA2 6118
Proximity Label-MS Homo sapiens
11 SAMD1  
Affinity Capture-MS Homo sapiens
12 CD79A  
Two-hybrid Homo sapiens
13 PTPN1 5770
Affinity Capture-MS Homo sapiens
14 SMAP2 64744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FFAR1  
Affinity Capture-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 PDE2A  
Affinity Capture-MS Homo sapiens
18 HYAL1 3373
Affinity Capture-MS Homo sapiens
19 CARKD 55739
Affinity Capture-MS Homo sapiens
20 SLC10A6  
Two-hybrid Homo sapiens
21 POLR1E  
Proximity Label-MS Homo sapiens
22 EXD2  
Proximity Label-MS Homo sapiens
23 MECP2 4204
Affinity Capture-MS Homo sapiens
24 KIR2DL3  
Two-hybrid Homo sapiens
25 GPX8 493869
Two-hybrid Homo sapiens
26 SDCBP 6386
Two-hybrid Homo sapiens
27 LAMTOR1 55004
Proximity Label-MS Homo sapiens
28 NUP155 9631
Proximity Label-MS Homo sapiens
29 KIAA1715 80856
Proximity Label-MS Homo sapiens
30 KCNK1  
Two-hybrid Homo sapiens
31 FCER1G 2207
Two-hybrid Homo sapiens
32 SLC16A7 9194
Two-hybrid Homo sapiens
33 SCAI  
Two-hybrid Homo sapiens
34 CTDP1 9150
Affinity Capture-MS Homo sapiens
35 JAGN1 84522
Two-hybrid Homo sapiens
36 NLRX1 79671
Affinity Capture-MS Homo sapiens
37 STAU1 6780
Affinity Capture-MS Homo sapiens
38 RELL2  
Two-hybrid Homo sapiens
39 TBC1D32 221322
Proximity Label-MS Homo sapiens
40 EVI2B 2124
Two-hybrid Homo sapiens
41 ODF4  
Two-hybrid Homo sapiens
42 UNC93A  
Two-hybrid Homo sapiens
43 NOS2  
Affinity Capture-MS Homo sapiens
44 GJB1 2705
Two-hybrid Homo sapiens
45 RPLP1 6176
Two-hybrid Homo sapiens
46 PCSK9 255738
Affinity Capture-MS Homo sapiens
47 TMEM56  
Two-hybrid Homo sapiens
48 ARL13B 200894
Two-hybrid Homo sapiens
49 GPR173  
Affinity Capture-MS Homo sapiens
50 UQCC1 55245
Affinity Capture-MS Homo sapiens
51 SLC7A1 6541
Two-hybrid Homo sapiens
52 CD3EAP  
Proximity Label-MS Homo sapiens
53 AQP2 359
Two-hybrid Homo sapiens
54 FFAR2  
Two-hybrid Homo sapiens
55 PANX1 24145
Proximity Label-MS Homo sapiens
56 MTIF3  
Two-hybrid Homo sapiens
57 SARM1 23098
Affinity Capture-MS Homo sapiens
58 IQCB1  
Affinity Capture-MS Homo sapiens
59 ERGIC3 51614
Two-hybrid Homo sapiens
60 HSD3B7 80270
Proximity Label-MS Homo sapiens
61 GPR101  
Two-hybrid Homo sapiens
62 NR3C1 2908
Proximity Label-MS Homo sapiens
63 SIGLEC12  
Two-hybrid Homo sapiens
64 EGFR 1956
Affinity Capture-MS Homo sapiens
65 ARF6 382
Proximity Label-MS Homo sapiens
66 HSD17B13  
Two-hybrid Homo sapiens
67 RIPK4  
Affinity Capture-MS Homo sapiens
68 GPR152  
Two-hybrid Homo sapiens
69 FAM209A 200232
Two-hybrid Homo sapiens
70 ATP6V0E1  
Two-hybrid Homo sapiens
71 MAPK6  
Affinity Capture-MS Homo sapiens
72 FAM134C 162427
Two-hybrid Homo sapiens
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 GPR45  
Affinity Capture-MS Homo sapiens
75 CPLX4  
Two-hybrid Homo sapiens
76 PSCA 8000
Two-hybrid Homo sapiens
77 DDRGK1 65992
Affinity Capture-MS Homo sapiens
78 ILK 3611
Affinity Capture-MS Homo sapiens
79 PEX3 8504
Proximity Label-MS Homo sapiens
80 HUWE1 10075
Affinity Capture-MS Homo sapiens
81 TMX2 51075
Two-hybrid Homo sapiens
82 VMA21  
Two-hybrid Homo sapiens
83 TMEM170A  
Affinity Capture-MS Homo sapiens
84 CLPP 8192
Proximity Label-MS Homo sapiens
85 NAAA  
Affinity Capture-MS Homo sapiens
86 PLP1 5354
Two-hybrid Homo sapiens
87 TTC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 FBXL6  
Affinity Capture-MS Homo sapiens
89 TP53 7157
Affinity Capture-MS Homo sapiens
90 RNF19B  
Two-hybrid Homo sapiens
91 DSCC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 IER3IP1 51124
Two-hybrid Homo sapiens
93 RTN3 10313
Two-hybrid Homo sapiens
94 CAPZA2 830
Affinity Capture-MS Homo sapiens
95 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
96 UNC93B1 81622
Affinity Capture-MS Homo sapiens
97 FCGR2A 2212
Two-hybrid Homo sapiens
98 EBP  
Two-hybrid Homo sapiens
99 C11orf52 91894
Proximity Label-MS Homo sapiens
100 MFF 56947
Two-hybrid Homo sapiens
101 EVA1C  
Affinity Capture-MS Homo sapiens
102 BSND  
Two-hybrid Homo sapiens
103 C16orf72 29035
Affinity Capture-MS Homo sapiens
104 AGPAT6 137964
Affinity Capture-MS Homo sapiens
105 ORC1  
Affinity Capture-MS Homo sapiens
106 SERBP1 26135
Affinity Capture-MS Homo sapiens
107 CISD2 493856
Two-hybrid Homo sapiens
108 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
109 RAB5C 5878
Proximity Label-MS Homo sapiens
110 C9orf72  
Affinity Capture-MS Homo sapiens
111 GOLM1 51280
Two-hybrid Homo sapiens
112 MS4A14  
Two-hybrid Homo sapiens
113 IGFBP6 3489
Two-hybrid Homo sapiens
114 PTPN18 26469
Affinity Capture-MS Homo sapiens
115 MGST3 4259
Two-hybrid Homo sapiens
116 DARS2 55157
Two-hybrid Homo sapiens
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