Gene description for PVRL1
Gene name poliovirus receptor-related 1 (herpesvirus entry mediator C)
Gene symbol PVRL1
Other names/aliases CD111
CLPED1
ED4
HIgR
HV1S
HVEC
OFC7
PRR
PRR1
PVRR
PVRR1
SK-12
nectin-1
Species Homo sapiens
 Database cross references - PVRL1
ExoCarta ExoCarta_5818
Vesiclepedia VP_5818
Entrez Gene 5818
HGNC 9706
MIM 600644
UniProt Q15223  
 PVRL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PVRL1
Molecular Function
    virus receptor activity GO:0001618 IDA
    protein binding GO:0005515 IPI
    coreceptor activity GO:0015026 TAS
    carbohydrate binding GO:0030246 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 ISS
    protein-containing complex binding GO:0044877 IEA
    virion binding GO:0046790 IEA
    cell adhesion molecule binding GO:0050839 IPI
    cell adhesion mediator activity GO:0098631 IDA
Biological Process
    lens morphogenesis in camera-type eye GO:0002089 IEA
    desmosome organization GO:0002934 IEA
    iron ion transport GO:0006826 IEA
    immune response GO:0006955 NAS
    cell adhesion GO:0007155 NAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IBA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    axon guidance GO:0007411 IEA
    symbiont entry into host cell GO:0046718 IDA
    symbiont entry into host cell GO:0046718 NAS
    regulation of synapse assembly GO:0051963 IEA
    retina development in camera-type eye GO:0060041 IEA
    enamel mineralization GO:0070166 IEA
    cochlea morphogenesis GO:0090103 ISS
    cell-cell adhesion GO:0098609 NAS
    protein localization to cell junction GO:1902414 IBA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    adherens junction GO:0005912 NAS
    membrane GO:0016020 NAS
    dendrite GO:0030425 IEA
    growth cone membrane GO:0032584 IEA
    apical junction complex GO:0043296 IEA
    cell-cell contact zone GO:0044291 IEA
    presynaptic active zone membrane GO:0048787 IEA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IEA
 Experiment description of studies that identified PVRL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PVRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBL 867
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 PICK1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 FGFR2 2263
Reconstituted Complex Homo sapiens
4 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CDH1 999
Proximity Label-MS Homo sapiens
6 FGFR1 2260
Reconstituted Complex Homo sapiens
7 MLLT4 4301
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 PVRL3 25945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FGFR3 2261
Reconstituted Complex Homo sapiens
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