Gene description for YES1
Gene name YES proto-oncogene 1, Src family tyrosine kinase
Gene symbol YES1
Other names/aliases HsT441
P61-YES
Yes
c-yes
Species Homo sapiens
 Database cross references - YES1
ExoCarta ExoCarta_7525
Vesiclepedia VP_7525
Entrez Gene 7525
HGNC 12841
MIM 164880
UniProt P07947  
 YES1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Saliva 19199708    
Squamous carcinoma cells 20124223    
Thymus 23844026    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for YES1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    transmembrane transporter binding GO:0044325 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    chromatin remodeling GO:0006338 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    regulation of D-glucose transmembrane transport GO:0010827 IEA
    cell differentiation GO:0030154 IBA
    T cell costimulation GO:0031295 TAS
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    protein modification process GO:0036211 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    regulation of vascular permeability GO:0043114 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    ephrin receptor signaling pathway GO:0048013 TAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    leukocyte migration GO:0050900 TAS
    cellular response to retinoic acid GO:0071300 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    focal adhesion GO:0005925 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified YES1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
24
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
25
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
33
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
34
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
36
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
37
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for YES1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Co-fractionation Homo sapiens
Affinity Capture-RNA Homo sapiens
2 MARCKS 4082
Proximity Label-MS Homo sapiens
3 FASLG 356
Protein-peptide Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 NPC2 10577
Affinity Capture-MS Homo sapiens
6 CEP57L1  
Two-hybrid Homo sapiens
7 PPP1CB 5500
Affinity Capture-MS Homo sapiens
8 SLFN11 91607
Proximity Label-MS Homo sapiens
9 PPIAL4G  
Affinity Capture-MS Homo sapiens
10 CAMKV 79012
Affinity Capture-MS Homo sapiens
11 OCLN 100506658
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 SHC1 6464
Affinity Capture-Western Homo sapiens
13 SNAP23 8773
Co-fractionation Homo sapiens
14 DUSP22  
Affinity Capture-MS Homo sapiens
15 LAMP3  
Proximity Label-MS Homo sapiens
16 SYNGR1 9145
Affinity Capture-MS Homo sapiens
17 GJA1 2697
Proximity Label-MS Homo sapiens
18 PIFO  
Affinity Capture-MS Homo sapiens
19 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
20 RCBTB2  
Affinity Capture-MS Homo sapiens
21 Calml3  
Affinity Capture-MS Mus musculus
22 DBN1 1627
Affinity Capture-MS Homo sapiens
23 EFS  
Two-hybrid Homo sapiens
24 RPL10 6134
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 KIF20A 10112
Affinity Capture-MS Homo sapiens
26 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
27 GAS8  
Two-hybrid Homo sapiens
28 LAMP2 3920
Proximity Label-MS Homo sapiens
29 SPRR2A  
Reconstituted Complex Homo sapiens
30 STAP2 55620
Two-hybrid Homo sapiens
31 SLC30A4 7782
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FFAR1  
Affinity Capture-MS Homo sapiens
33 MTRF1  
Affinity Capture-MS Homo sapiens
34 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
35 WDR36 134430
Affinity Capture-MS Homo sapiens
36 ILF2 3608
Co-fractionation Homo sapiens
37 B3GAT1  
Proximity Label-MS Homo sapiens
38 DTX3  
Two-hybrid Homo sapiens
39 JAKMIP1 152789
Two-hybrid Homo sapiens
40 Trim69  
Affinity Capture-MS Mus musculus
41 KIF23 9493
Affinity Capture-MS Homo sapiens
42 ERBB2 2064
Reconstituted Complex Homo sapiens
43 SPIN1  
Affinity Capture-MS Homo sapiens
44 CXADR 1525
Proximity Label-MS Homo sapiens
45 ERAP1 51752
Co-fractionation Homo sapiens
46 ZNF512B  
Two-hybrid Homo sapiens
47 KHDRBS1 10657
Protein-peptide Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
48 GPRC5B 51704
Affinity Capture-MS Homo sapiens
49 RHOA 387
Co-fractionation Homo sapiens
50 STX4 6810
Affinity Capture-MS Homo sapiens
51 STIP1 10963
Co-fractionation Homo sapiens
52 KRAS 3845
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
53 JSRP1  
Affinity Capture-MS Homo sapiens
54 KIFAP3 22920
Affinity Capture-MS Homo sapiens
55 CTTN 2017
Affinity Capture-Western Homo sapiens
56 NIF3L1 60491
Two-hybrid Homo sapiens
57 Mbp 17196
Protein-peptide Mus musculus
58 ZNF438  
Two-hybrid Homo sapiens
59 RAB35 11021
Proximity Label-MS Homo sapiens
60 TFCP2 7024
Affinity Capture-MS Homo sapiens
61 CBLB 868
Two-hybrid Homo sapiens
62 FAF2 23197
Co-fractionation Homo sapiens
63 FGFR1 2260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
64 NEDD4 4734
Reconstituted Complex Homo sapiens
65 NCSTN 23385
Affinity Capture-MS Homo sapiens
66 FAM20C 56975
Affinity Capture-MS Homo sapiens
67 SIK2  
Affinity Capture-MS Homo sapiens
68 DVL2 1856
Two-hybrid Homo sapiens
69 DYNLT1 6993
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
70 KIF14 9928
Affinity Capture-MS Homo sapiens
71 DENND2C  
Two-hybrid Homo sapiens
72 ANKRD12  
Affinity Capture-MS Homo sapiens
73 LMAN1 3998
Proximity Label-MS Homo sapiens
74 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
75 CENPK  
Affinity Capture-MS Homo sapiens
76 AMOTL2 51421
Two-hybrid Homo sapiens
77 GFAP 2670
Two-hybrid Homo sapiens
78 NSUN2 54888
Co-fractionation Homo sapiens
79 KIT 3815
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
80 CYP2S1  
Affinity Capture-MS Homo sapiens
81 ZCCHC9  
Affinity Capture-MS Homo sapiens
82 PARK2  
Affinity Capture-MS Homo sapiens
83 NPHS1 4868
Affinity Capture-Western Homo sapiens
84 ERBB3 2065
Reconstituted Complex Homo sapiens
85 STOM 2040
Affinity Capture-MS Homo sapiens
86 SOCS7  
Two-hybrid Homo sapiens
87 CCDC33 80125
Two-hybrid Homo sapiens
88 LYN 4067
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
89 MAPRE1 22919
Affinity Capture-MS Homo sapiens
90 MCAM 4162
Proximity Label-MS Homo sapiens
91 CBL 867
Reconstituted Complex Homo sapiens
92 GPR35  
Affinity Capture-MS Homo sapiens
93 CERS2 29956
Affinity Capture-MS Homo sapiens
94 GJB7  
Affinity Capture-MS Homo sapiens
95 DNAJC5 80331
Proximity Label-MS Homo sapiens
96 SYT3  
Affinity Capture-MS Homo sapiens
97 CDH1 999
Reconstituted Complex Homo sapiens
98 FYN 2534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
99 YAP1 10413
Affinity Capture-MS Homo sapiens
100 MYH9 4627
Affinity Capture-MS Homo sapiens
101 OGT 8473
Biochemical Activity Homo sapiens
102 LIN7C 55327
Two-hybrid Homo sapiens
103 CENPM  
Affinity Capture-MS Homo sapiens
104 DTX2 113878
Proximity Label-MS Homo sapiens
105 RLIM 51132
Affinity Capture-MS Homo sapiens
106 PTPRE 5791
Affinity Capture-MS Homo sapiens
107 STX6 10228
Proximity Label-MS Homo sapiens
108 AIP 9049
Affinity Capture-MS Homo sapiens
109 PIK3R1 5295
Affinity Capture-Western Homo sapiens
110 Coro1c 23790
Affinity Capture-MS Mus musculus
111 Sidt2  
Affinity Capture-MS Mus musculus
112 PIGM  
Affinity Capture-MS Homo sapiens
113 LIMCH1 22998
Affinity Capture-MS Homo sapiens
114 ATP6V1E1 529
Co-fractionation Homo sapiens
115 FGFR1OP  
Affinity Capture-MS Homo sapiens
116 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 FLRT1  
Affinity Capture-MS Homo sapiens
118 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 LIMA1 51474
Affinity Capture-MS Homo sapiens
120 RBBP6 5930
Affinity Capture-MS Homo sapiens
121 DOK2 9046
Two-hybrid Homo sapiens
122 OLA1 29789
Co-fractionation Homo sapiens
123 SOCS2  
Two-hybrid Homo sapiens
124 F2RL1  
Affinity Capture-MS Homo sapiens
125 ATP6V0D2 245972
Affinity Capture-MS Homo sapiens
126 FUNDC1  
Two-hybrid Homo sapiens
127 RAB5A 5868
Proximity Label-MS Homo sapiens
128 PECAM1 5175
Affinity Capture-Western Homo sapiens
129 IKZF3  
Two-hybrid Homo sapiens
130 HOXB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 CCDC186 55088
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 TUBD1  
Affinity Capture-MS Homo sapiens
133 NAT10 55226
Affinity Capture-MS Homo sapiens
134 LAMP1 3916
Proximity Label-MS Homo sapiens
135 NFKBIA  
Affinity Capture-MS Homo sapiens
136 Bmpr1a  
Affinity Capture-MS Mus musculus
137 PCDHGC3 5098
Affinity Capture-MS Homo sapiens
138 TRAF6 7189
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
139 ERLEC1 27248
Affinity Capture-MS Homo sapiens
140 DES 1674
Two-hybrid Homo sapiens
141 ERBB4 2066
Reconstituted Complex Homo sapiens
142 PDLIM7 9260
Affinity Capture-MS Homo sapiens
143 EGFR 1956
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
144 SOCS1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
145 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 ARF6 382
Proximity Label-MS Homo sapiens
147 PTK2 5747
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
148 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 FAM13A 10144
Affinity Capture-MS Homo sapiens
150 SOCS3 9021
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
151 FTH1 2495
Affinity Capture-MS Homo sapiens
152 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 FN1 2335
Affinity Capture-MS Homo sapiens
154 GAB1  
Reconstituted Complex Homo sapiens
155 THAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
156 CYP51A1 1595
Affinity Capture-MS Homo sapiens
157 MYCN  
Affinity Capture-MS Homo sapiens
158 KCNE3  
Affinity Capture-MS Homo sapiens
159 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 CCNL2 81669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 ACSL3 2181
Affinity Capture-Western Homo sapiens
162 Flnb 286940
Affinity Capture-MS Mus musculus
163 MYC  
Dosage Lethality Homo sapiens
Affinity Capture-MS Homo sapiens
164 RPA3 6119
Proximity Label-MS Homo sapiens
165 FXR2 9513
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
166 RAB9A 9367
Proximity Label-MS Homo sapiens
167 BLMH 642
Affinity Capture-MS Homo sapiens
168 C1orf94  
Two-hybrid Homo sapiens
169 MET 4233
Reconstituted Complex Homo sapiens
170 CDK20  
Affinity Capture-MS Homo sapiens
171 SH3GLB2 56904
Two-hybrid Homo sapiens
172 RHOB 388
Proximity Label-MS Homo sapiens
173 FYTTD1  
Affinity Capture-MS Homo sapiens
174 SLC16A14  
Affinity Capture-MS Homo sapiens
175 TRPV4 59341
Affinity Capture-Western Homo sapiens
176 DIRAS3  
Proximity Label-MS Homo sapiens
177 Ppp1cb 19046
Affinity Capture-MS Mus musculus
178 TSR1 55720
Co-fractionation Homo sapiens
179 TMEM59 9528
Affinity Capture-MS Homo sapiens
180 CSF1R  
Affinity Capture-Western Homo sapiens
181 FLOT1 10211
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
182 MALL  
Affinity Capture-MS Homo sapiens
183 SOX2  
Affinity Capture-MS Homo sapiens
184 SLC14A1  
Affinity Capture-MS Homo sapiens
185 CD46 4179
Affinity Capture-Western Homo sapiens
186 CBLC  
Two-hybrid Homo sapiens
187 RASA1 5921
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
188 TRIM5 85363
Two-hybrid Homo sapiens
189 TGFBR2 7048
Affinity Capture-MS Homo sapiens
190 TNK2 10188
Reconstituted Complex Homo sapiens
191 SLC25A11 8402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 GRPEL2  
Affinity Capture-MS Homo sapiens
193 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 C3orf14  
Affinity Capture-MS Homo sapiens
195 TRAF2 7186
Two-hybrid Homo sapiens
196 LAMTOR1 55004
Proximity Label-MS Homo sapiens
197 Sod1 20655
Affinity Capture-MS Mus musculus
198 TSGA10IP  
Two-hybrid Homo sapiens
199 CPSF6 11052
Two-hybrid Homo sapiens
200 OPALIN  
Affinity Capture-MS Homo sapiens
201 PDCD6IP 10015
Affinity Capture-Western Homo sapiens
202 ZBTB8A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
203 FXR1 8087
Two-hybrid Homo sapiens
204 FAS 355
Affinity Capture-Western Homo sapiens
205 EPHB2 2048
Reconstituted Complex Homo sapiens
206 RP2 6102
Affinity Capture-MS Homo sapiens
207 CDC37 11140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 ALS2CR12  
Two-hybrid Homo sapiens
209 ZC2HC1A 51101
Two-hybrid Homo sapiens
210 FLOT2 2319
Affinity Capture-MS Homo sapiens
211 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
212 BTF3 689
Affinity Capture-MS Homo sapiens
213 ZDHHC23  
Affinity Capture-MS Homo sapiens
214 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
215 STK38L 23012
Affinity Capture-MS Homo sapiens
216 IL1R1 3554
Affinity Capture-Western Homo sapiens
217 ADAM15 8751
Reconstituted Complex Homo sapiens
218 C11orf52 91894
Proximity Label-MS Homo sapiens
219 SSBP3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
220 CD36 948
Affinity Capture-Western Homo sapiens
221 CARD9 64170
Two-hybrid Homo sapiens
222 DOK1 1796
Reconstituted Complex Homo sapiens
223 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
224 RAB2A 5862
Proximity Label-MS Homo sapiens
225 GLUL 2752
Co-fractionation Homo sapiens
226 BICD2 23299
Two-hybrid Homo sapiens
227 DNAJC5B  
Proximity Label-MS Homo sapiens
228 ARRB1 408
Affinity Capture-MS Homo sapiens
229 ZPBP2  
Affinity Capture-MS Homo sapiens
230 CDK9 1025
Affinity Capture-MS Homo sapiens
231 Lck 16818
Affinity Capture-MS Mus musculus
232 RAB11A 8766
Proximity Label-MS Homo sapiens
233 SLC9A3R1 9368
Reconstituted Complex Homo sapiens
234 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
235 EPHA2 1969
Proximity Label-MS Homo sapiens
236 PGM3 5238
Co-fractionation Homo sapiens
237 ACBD7  
Affinity Capture-MS Homo sapiens
238 EZR 7430
Proximity Label-MS Homo sapiens
239 CUL7 9820
Affinity Capture-MS Homo sapiens
240 PRUNE2  
Affinity Capture-MS Homo sapiens
241 RAB5C 5878
Proximity Label-MS Homo sapiens
242 CEP83  
Two-hybrid Homo sapiens
243 AR 367
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
244 DDIT4L  
Two-hybrid Homo sapiens
245 MLLT4 4301
Proximity Label-MS Homo sapiens
246 PCDHB3  
Affinity Capture-MS Homo sapiens
247 CCR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
248 CAV1 857
Proximity Label-MS Homo sapiens
249 PIK3R3 8503
Two-hybrid Homo sapiens
250 C1QL4  
Affinity Capture-MS Homo sapiens
251 CTNND1 1500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
252 CHMP1A 5119
Two-hybrid Homo sapiens
253 MED28  
Affinity Capture-Western Homo sapiens
254 FGR 2268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which YES1 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
CD28 co-stimulation TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse TAS Reactome
EPHA-mediated growth cone collapse IEA Reactome
EPHB-mediated forward signaling TAS Reactome
EPHB-mediated forward signaling IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR activation TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PECAM1 interactions TAS Reactome
Regulation of KIT signaling TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by ERBB2 TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by SCF-KIT IEA Reactome
Transcriptional regulation by RUNX2 IEA Reactome





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