Gene description for Ppp2r2a
Gene name protein phosphatase 2, regulatory subunit B, alpha
Gene symbol Ppp2r2a
Other names/aliases 2410004D02Rik
mKIAA1541
Species Mus musculus
 Database cross references - Ppp2r2a
ExoCarta ExoCarta_71978
Vesiclepedia VP_71978
Entrez Gene 71978
UniProt Q6P1F6  
 Ppp2r2a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppp2r2a
Molecular Function
    protein phosphatase regulator activity GO:0019888 IBA
    protein phosphatase regulator activity GO:0019888 IDA
    protein phosphatase regulator activity GO:0019888 ISO
    protein-containing complex binding GO:0044877 ISO
    tau protein binding GO:0048156 ISO
    protein phosphatase 2A binding GO:0051721 ISO
    enzyme-substrate adaptor activity GO:0140767 IDA
Biological Process
    protein dephosphorylation GO:0006470 ISO
    protein dephosphorylation GO:0006470 ISS
    response to morphine GO:0043278 IMP
    regulation of chromosome segregation GO:0051983 IDA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 IDA
    protein phosphatase type 2A complex GO:0000159 ISO
    cytosol GO:0005829 IBA
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Ppp2r2a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppp2r2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Cct3 12462
Co-fractionation Mus musculus
3 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Thumpd1  
Co-fractionation Mus musculus
6 S100a9 20202
Co-fractionation Mus musculus
7 Fbxl16  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
8 Mapt  
Affinity Capture-MS Mus musculus
9 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
10 Cct8 12469
Co-fractionation Mus musculus
11 Ppp2cb 19053
Affinity Capture-Western Mus musculus
12 Strn3  
Co-fractionation Mus musculus
13 FAM122A  
Affinity Capture-MS Homo sapiens
14 Fancd2  
Affinity Capture-MS Mus musculus
15 Kctd13  
Affinity Capture-MS Mus musculus
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