Gene description for Cnn3
Gene name calponin 3, acidic
Gene symbol Cnn3
Other names/aliases 1600014M03Rik
C85854
Calpo3
Species Mus musculus
 Database cross references - Cnn3
ExoCarta ExoCarta_71994
Vesiclepedia VP_71994
Entrez Gene 71994
UniProt Q9DAW9  
 Cnn3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cnn3
Molecular Function
    actin binding GO:0003779 IEA
    calmodulin binding GO:0005516 IEA
    microtubule binding GO:0008017 IEA
    microtubule binding GO:0008017 ISO
    actin filament binding GO:0051015 IBA
Biological Process
    actin filament organization GO:0007015 IBA
    epithelial cell differentiation GO:0030855 IEA
    actomyosin structure organization GO:0031032 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    dendrite GO:0030425 ISO
    neuronal cell body GO:0043025 IEA
    neuronal cell body GO:0043025 ISO
    dendritic spine GO:0043197 IEA
    dendritic spine GO:0043197 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Cnn3 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cnn3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nufip2  
Two-hybrid Mus musculus
2 SPATS2  
Two-hybrid Homo sapiens
3 EXOSC7 23016
Two-hybrid Homo sapiens
4 Lmna 16905
Affinity Capture-MS Mus musculus
5 Pou5f1  
Affinity Capture-MS Mus musculus
6 DMRTB1  
Two-hybrid Homo sapiens
7 Cstf2t  
Two-hybrid Mus musculus
8 Eif3g 53356
Two-hybrid Mus musculus
9 PRPF6 24148
Two-hybrid Homo sapiens
10 Atxn1  
Affinity Capture-MS Mus musculus
11 Foxp3  
Affinity Capture-MS Mus musculus
12 Rbm14  
Two-hybrid Mus musculus
13 CEP55 55165
Two-hybrid Homo sapiens
14 Gfm2  
Co-fractionation Mus musculus
15 Nudt21 68219
Two-hybrid Mus musculus
16 PRRC2B  
Two-hybrid Homo sapiens
17 Mettl21e  
Affinity Capture-MS Mus musculus
18 Mapre1 13589
Two-hybrid Mus musculus
19 CPSF7 79869
Two-hybrid Homo sapiens
20 Pef1  
Two-hybrid Mus musculus
21 Eed  
Affinity Capture-MS Mus musculus
22 CSDE1 7812
Two-hybrid Homo sapiens
23 TFIP11  
Two-hybrid Homo sapiens
24 Pspc1  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Cnn3 is involved
No pathways found





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