Gene description for Ipo4
Gene name importin 4
Gene symbol Ipo4
Other names/aliases 8430408O15Rik
AA409693
Imp4a
RanBP4
Species Mus musculus
 Database cross references - Ipo4
ExoCarta ExoCarta_75751
Vesiclepedia VP_75751
Entrez Gene 75751
UniProt Q8VI75  
 Ipo4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ipo4
Molecular Function
    protein binding GO:0005515 IPI
    nuclear localization sequence binding GO:0008139 IBA
    nuclear localization sequence binding GO:0008139 ISO
    nuclear localization sequence binding GO:0008139 ISS
    small GTPase binding GO:0031267 IEA
    nuclear import signal receptor activity GO:0061608 IBA
    nuclear import signal receptor activity GO:0061608 ISO
    nuclear import signal receptor activity GO:0061608 ISS
Biological Process
    protein import into nucleus GO:0006606 IBA
    protein import into nucleus GO:0006606 ISO
    protein import into nucleus GO:0006606 ISO
    ribosome biogenesis GO:0042254 ISO
Subcellular Localization
    chromatin GO:0000785 IEA
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Ipo4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ipo4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Cyfip1 20430
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Tnpo1 238799
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ipo4 is involved
No pathways found





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