Gene description for PRKRIP1
Gene name PRKR interacting protein 1 (IL11 inducible)
Gene symbol PRKRIP1
Other names/aliases C114
KRBOX3
Species Homo sapiens
 Database cross references - PRKRIP1
ExoCarta ExoCarta_79706
Vesiclepedia VP_79706
Entrez Gene 79706
HGNC 21894
UniProt Q9H875  
 PRKRIP1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PRKRIP1
Molecular Function
    double-stranded RNA binding GO:0003725 IBA
    double-stranded RNA binding GO:0003725 ISS
    protein kinase inhibitor activity GO:0004860 IBA
    protein kinase inhibitor activity GO:0004860 ISS
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 ISS
Biological Process
    renal system process GO:0003014 IDA
    mRNA processing GO:0006397 IEA
    negative regulation of protein kinase activity GO:0006469 ISS
    RNA splicing GO:0008380 IEA
    negative regulation of phosphorylation GO:0042326 ISS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IEA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PRKRIP1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PRKRIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 IKBKAP 8518
Co-fractionation Homo sapiens
4 SNX27 81609
Affinity Capture-MS Homo sapiens
5 MYCN  
Affinity Capture-MS Homo sapiens
6 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TRAF2 7186
Two-hybrid Homo sapiens
8 FEM1A  
Affinity Capture-MS Homo sapiens
9 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 GSK3B 2932
Two-hybrid Homo sapiens
11 XPO1 7514
Affinity Capture-MS Homo sapiens
12 MAGEA11  
Two-hybrid Homo sapiens
13 ZNF217 7764
Co-fractionation Homo sapiens
14 RNU11 26824
Affinity Capture-MS Homo sapiens
15 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
16 PDGFRA 5156
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 APEX1 328
Affinity Capture-RNA Homo sapiens
19 SNRPB 6628
Co-fractionation Homo sapiens
20 CEP70  
Two-hybrid Homo sapiens
21 MCM2 4171
Co-fractionation Homo sapiens
22 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SNRPA1 6627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CEBPA  
Protein-peptide Homo sapiens
25 LRP8 7804
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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