Experiment description of studies that identified TTI2 in sEVs

1 Experiment ID 226 MISEV standards ✔ EM Biophysical techniques ✔ GAPDH|CD9|FLOT1 Enriched markers ✔ LMNA|H2AFX|ATP5A1|TOMM20 Negative markers ✘ Particle analysis Identified molecule mRNA Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa) PubMed ID 26027894     Organism Homo sapiens Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting" Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar" Journal name Journal of Extracellular Vesicles Publication year 2015 Sample Endothelial cells Sample name HMEC-1 Isolation/purification methods Differential ultracentrifugation Sucrose density gradient Flotation density 1.10 g/mL Molecules identified in the study miRNA Protein snoRNA lncRNA yRNA snRNA mRNA ncRNA mtRNA vtRNA scaRNA lincRNA Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa) Western blotting

2 Experiment ID 217 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|CD81|CD9|CD63 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23844026     Organism Homo sapiens Experiment description Characterization of human thymic exosomes. Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O." Journal name PLoS One Publication year 2013 Sample Thymus Sample name Normal-Thymus Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for TTI2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 LRRTM2   Affinity Capture-MS Homo sapiens 2 GYPA   Affinity Capture-MS Homo sapiens 3 TTI1 9675 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 4 CD40 958 Affinity Capture-MS Homo sapiens 5 LYPD3 27076 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 6 PLEKHA4 57664 Affinity Capture-MS Homo sapiens 7 Ruvbl2 20174 Affinity Capture-MS Mus musculus 8 OCIAD1 54940 Affinity Capture-MS Homo sapiens 9 EFNA4   Affinity Capture-MS Homo sapiens 10 APLNR   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 11 Ruvbl1 56505 Affinity Capture-MS Mus musculus 12 TRRAP 8295 Affinity Capture-MS Homo sapiens 13 LDLRAD1   Affinity Capture-MS Homo sapiens 14 RUVBL2 10856 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 15 RIT1 6016 Negative Genetic Homo sapiens 16 LRRC25   Affinity Capture-MS Homo sapiens 17 BSG 682 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 18 NPTN 27020 Affinity Capture-MS Homo sapiens 19 SLC2A1 6513 Affinity Capture-MS Homo sapiens 20 FPR1   Affinity Capture-MS Homo sapiens 21 TYROBP   Affinity Capture-MS Homo sapiens 22 EGFR 1956 Affinity Capture-MS Homo sapiens 23 ELAVL1 1994 Affinity Capture-RNA Homo sapiens 24 TNFSF12 8742 Affinity Capture-MS Homo sapiens 25 FUS 2521 Affinity Capture-MS Homo sapiens 26 GPRC5D   Affinity Capture-MS Homo sapiens 27 PRKDC 5591 Affinity Capture-MS Homo sapiens 28 SLC39A9 55334 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 29 CD80 941 Affinity Capture-MS Homo sapiens 30 HSPA4 3308 Affinity Capture-MS Homo sapiens 31 SLC18A2   Affinity Capture-MS Homo sapiens 32 OSBPL3 26031 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 33 RUVBL1 8607 Affinity Capture-MS Homo sapiens 34 GPR17 2840 Affinity Capture-MS Homo sapiens 35 HSP90AA1 3320 Affinity Capture-MS Homo sapiens 36 GPR45   Affinity Capture-MS Homo sapiens 37 GPR182   Affinity Capture-MS Homo sapiens 38 TNFRSF10C   Affinity Capture-MS Homo sapiens 39 RPAP3 79657 Affinity Capture-MS Homo sapiens 40 TELO2 9894 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 41 PIH1D1   Affinity Capture-MS Homo sapiens 42 OPRM1 4988 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 43 KRAS 3845 Synthetic Lethality Homo sapiens Negative Genetic Homo sapiens 44 KLRC1   Affinity Capture-MS Homo sapiens 45 GPR84   Affinity Capture-MS Homo sapiens 46 TACSTD2 4070 Affinity Capture-MS Homo sapiens View the network

Pathways in which TTI2 is involved

No pathways found