Gene description for SBF2
Gene name SET binding factor 2
Gene symbol SBF2
Other names/aliases CMT4B2
DENND7B
MTMR13
Species Homo sapiens
 Database cross references - SBF2
ExoCarta ExoCarta_81846
Vesiclepedia VP_81846
Entrez Gene 81846
HGNC 2135
MIM 607697
UniProt Q86WG5  
 SBF2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SBF2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
    phosphatase regulator activity GO:0019208 IEA
    phosphatase binding GO:0019902 IEA
    phosphatidylinositol binding GO:0035091 IEA
    identical protein binding GO:0042802 IEA
Biological Process
    autophagy GO:0006914 IEA
    myelination GO:0042552 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    vacuolar membrane GO:0005774 IEA
    cytosol GO:0005829 TAS
    endosome membrane GO:0010008 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    axon GO:0030424 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SBF2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SBF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPD 3184
Affinity Capture-MS Homo sapiens
2 H2AFY2 55506
Proximity Label-MS Homo sapiens
3 RAB35 11021
Proximity Label-MS Homo sapiens
4 FTO 79068
Proximity Label-MS Homo sapiens
5 FBXW11  
Affinity Capture-MS Homo sapiens
6 AK2 204
Proximity Label-MS Homo sapiens
7 Mtmr2  
Affinity Capture-MS Mus musculus
8 FBXO7 25793
Affinity Capture-MS Homo sapiens
9 PMS1  
Affinity Capture-Western Homo sapiens
10 TP53 7157
Synthetic Growth Defect Homo sapiens
11 G6PD 2539
Proximity Label-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 BAG5 9529
Proximity Label-MS Homo sapiens
14 UBA1 7317
Proximity Label-MS Homo sapiens
15 FHL3 2275
Two-hybrid Homo sapiens
16 UBC 7316
Reconstituted Complex Homo sapiens
17 TXNDC12 51060
Proximity Label-MS Homo sapiens
18 METTL21B  
Affinity Capture-MS Homo sapiens
19 SBF1 6305
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
20 BAG6 7917
Affinity Capture-MS Homo sapiens
21 PMPCB 9512
Proximity Label-MS Homo sapiens
22 LSM7  
Affinity Capture-MS Homo sapiens
23 DHFR 1719
Affinity Capture-MS Homo sapiens
24 INF2 64423
Affinity Capture-MS Homo sapiens
25 NTRK1 4914
Affinity Capture-MS Homo sapiens
26 SORT1 6272
Affinity Capture-MS Homo sapiens
27 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
28 FBXW7  
Affinity Capture-MS Homo sapiens
29 MTMR1 8776
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
30 MTMR2 8898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
31 SLC31A1 1317
Affinity Capture-MS Homo sapiens
32 RBPMS 11030
Two-hybrid Homo sapiens
33 DCTPP1 79077
Proximity Label-MS Homo sapiens
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