Gene description for Trps1
Gene name trichorhinophalangeal syndrome I (human)
Gene symbol Trps1
Other names/aliases AI115454
AI447310
D15Ertd586e
Species Mus musculus
 Database cross references - Trps1
ExoCarta ExoCarta_83925
Vesiclepedia VP_83925
Entrez Gene 83925
 Trps1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trps1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    DNA-binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    protein domain specific binding GO:0019904 ISO
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    skeletal system development GO:0001501 ISO
    hair follicle development GO:0001942 IMP
    chondrocyte differentiation GO:0002062 IGI
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cell surface receptor protein serine/threonine kinase signaling pathway GO:0007178 IGI
    regulation of chondrocyte differentiation GO:0032330 IMP
    negative regulation of DNA-templated transcription GO:0045892 IMP
    negative regulation of DNA-templated transcription GO:0045892 IPI
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IGI
Subcellular Localization
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Trps1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ncoa3  
Two-hybrid Mus musculus
2 Rnf4  
Two-hybrid Mus musculus
3 Zfp236  
Two-hybrid Mus musculus
4 Zbtb7b  
Affinity Capture-MS Mus musculus
5 Usp7  
Affinity Capture-MS Mus musculus
6 Dynll1 56455
Two-hybrid Mus musculus
7 Ewsr1 14030
Two-hybrid Mus musculus
8 Trpm2 28240
Co-fractionation Mus musculus
9 Tlx3  
Two-hybrid Mus musculus
10 Lama5 16776
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Trps1 is involved
No pathways found





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