Gene description for Lama5
Gene name laminin, alpha 5
Gene symbol Lama5
Other names/aliases AA408760
AA408762
AI853660
[a]5
laminin-511
mKIAA0533
Species Mus musculus
 Database cross references - Lama5
ExoCarta ExoCarta_16776
Vesiclepedia VP_16776
Entrez Gene 16776
UniProt Q61001  
 Lama5 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Lama5
Molecular Function
    integrin binding GO:0005178 IDA
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 IBA
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
Biological Process
    branching involved in ureteric bud morphogenesis GO:0001658 IMP
    morphogenesis of a polarized epithelium GO:0001738 IMP
    neural crest cell migration GO:0001755 IMP
    kidney development GO:0001822 IMP
    hair follicle development GO:0001942 IMP
    integrin-mediated signaling pathway GO:0007229 IEA
    integrin-mediated signaling pathway GO:0007229 ISO
    axon guidance GO:0007411 IBA
    muscle organ development GO:0007517 IMP
    animal organ morphogenesis GO:0009887 IBA
    animal organ morphogenesis GO:0009887 IMP
    tissue development GO:0009888 IBA
    morphogenesis of embryonic epithelium GO:0016331 IMP
    cell migration GO:0016477 ISO
    regulation of cell adhesion GO:0030155 IEA
    lung development GO:0030324 IMP
    regulation of cell migration GO:0030334 IEA
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    trunk neural crest cell migration GO:0036484 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IMP
    regulation of embryonic development GO:0045995 IEA
    skeletal system morphogenesis GO:0048705 IEA
    skeletal system morphogenesis GO:0048705 ISO
    branching morphogenesis of an epithelial tube GO:0048754 IMP
    regulation of epithelial cell proliferation GO:0050678 IMP
    cilium assembly GO:0060271 IMP
    branching involved in salivary gland morphogenesis GO:0060445 IMP
    protein localization to plasma membrane GO:0072659 IMP
    postsynapse organization GO:0099173 IDA
    postsynapse organization GO:0099173 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    basement membrane GO:0005604 IBA
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 ISO
    laminin-5 complex GO:0005610 IEA
    laminin-5 complex GO:0005610 ISO
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 IDA
    neuromuscular junction GO:0031594 IDA
    synaptic cleft GO:0043083 IDA
    laminin-10 complex GO:0043259 IPI
    laminin-10 complex GO:0043259 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular matrix of synaptic cleft GO:0098965 IDA
    extracellular matrix of synaptic cleft GO:0098965 IEP
    extracellular matrix of synaptic cleft GO:0098965 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Lama5 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lama5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atp6ap1  
Co-fractionation Mus musculus
2 Adgre5 26364
Co-fractionation Mus musculus
3 Col5a1 12831
Co-fractionation Mus musculus
4 Itga6 16403
Co-fractionation Mus musculus
5 Eed  
Affinity Capture-MS Mus musculus
6 Dnase2a  
Co-fractionation Mus musculus
7 Lamb1 16777
Co-fractionation Mus musculus
8 Ggnbp2  
Co-fractionation Mus musculus
9 Itgb4  
Co-fractionation Mus musculus
10 Lamb2 16779
Co-fractionation Mus musculus
11 Fbn1  
Co-fractionation Mus musculus
12 Plxnb2 140570
Co-fractionation Mus musculus
13 Trps1 83925
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Lama5 is involved
No pathways found





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