Gene description for Lamb1
Gene name laminin B1
Gene symbol Lamb1
Other names/aliases C77966
C80098
C81607
D130003D08Rik
Lamb-1
Lamb1-1
Species Mus musculus
 Database cross references - Lamb1
ExoCarta ExoCarta_16777
Vesiclepedia VP_16777
Entrez Gene 16777
UniProt P02469  
 Lamb1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lamb1
Molecular Function
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IMP
    extracellular matrix structural constituent GO:0005201 ISO
    extracellular matrix structural constituent GO:0005201 ISS
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    glycosphingolipid binding GO:0043208 IDA
Biological Process
    cell adhesion GO:0007155 IEA
    negative regulation of cell adhesion GO:0007162 IDA
    axon guidance GO:0007411 IBA
    embryo implantation GO:0007566 IMP
    learning or memory GO:0007611 NAS
    animal organ morphogenesis GO:0009887 IBA
    tissue development GO:0009888 IBA
    cell migration GO:0016477 IBA
    cell migration GO:0016477 IMP
    neuronal-glial interaction involved in cerebral cortex radial glia guided migration GO:0021812 ISO
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of cell migration GO:0030335 ISS
    neuron projection development GO:0031175 IDA
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    substrate adhesion-dependent cell spreading GO:0034446 IBA
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    odontogenesis GO:0042476 ISO
    odontogenesis GO:0042476 ISS
    positive regulation of cell adhesion GO:0045785 NAS
    positive regulation of muscle cell differentiation GO:0051149 NAS
    basement membrane assembly GO:0070831 IBA
    regulation of basement membrane organization GO:0110011 NAS
    positive regulation of integrin-mediated signaling pathway GO:2001046 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 ISO
    basement membrane GO:0005604 ISS
    basement membrane GO:0005604 NAS
    laminin-1 complex GO:0005606 IDA
    laminin-1 complex GO:0005606 ISO
    laminin-1 complex GO:0005606 ISS
    laminin-2 complex GO:0005607 ISO
    laminin-2 complex GO:0005607 ISS
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IDA
    extracellular matrix GO:0031012 IDA
    laminin complex GO:0043256 IBA
    laminin complex GO:0043256 IDA
    laminin-8 complex GO:0043257 ISO
    laminin-8 complex GO:0043257 ISS
    laminin-10 complex GO:0043259 IPI
    laminin-10 complex GO:0043259 ISO
    laminin-10 complex GO:0043259 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 ISO
    protein complex involved in cell-matrix adhesion GO:0098637 NAS
 Experiment description of studies that identified Lamb1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lamb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lamc1 226519
Co-fractionation Mus musculus
2 ANOS1 3730
Reconstituted Complex Homo sapiens
3 Ndn  
Two-hybrid Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Lama1  
Affinity Capture-Western Mus musculus
6 Atg5  
Affinity Capture-RNA Mus musculus
7 Pou5f1  
Affinity Capture-MS Mus musculus
8 Itga6 16403
Co-fractionation Mus musculus
9 Itgb4  
Co-fractionation Mus musculus
10 Lama5 16776
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Lamb1 is involved
No pathways found





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