Gene description for Lamc1
Gene name laminin, gamma 1
Gene symbol Lamc1
Other names/aliases Lamb2
Species Mus musculus
 Database cross references - Lamc1
ExoCarta ExoCarta_226519
Vesiclepedia VP_226519
Entrez Gene 226519
 Lamc1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lamc1
Molecular Function
    extracellular matrix structural constituent GO:0005201 ISO
    extracellular matrix structural constituent GO:0005201 ISS
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    glycosphingolipid binding GO:0043208 IDA
Biological Process
    chromatin organization GO:0006325 IMP
    cell adhesion GO:0007155 ISO
    cell adhesion GO:0007155 ISS
    axon guidance GO:0007411 IBA
    animal organ morphogenesis GO:0009887 IBA
    tissue development GO:0009888 IBA
    gene expression GO:0010467 IMP
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    extracellular matrix disassembly GO:0022617 ISO
    extracellular matrix disassembly GO:0022617 ISS
    hair follicle morphogenesis GO:0031069 IMP
    neuron projection development GO:0031175 IDA
    hemidesmosome assembly GO:0031581 ISO
    hemidesmosome assembly GO:0031581 ISS
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    hair cell differentiation GO:0035315 IMP
    positive regulation of cell adhesion GO:0045785 NAS
    tissue morphogenesis GO:0048729 IMP
    positive regulation of muscle cell differentiation GO:0051149 NAS
    protein-containing complex assembly GO:0065003 ISO
    protein-containing complex assembly GO:0065003 ISS
    hair follicle cell proliferation GO:0071335 IMP
    regulation of basement membrane organization GO:0110011 NAS
    positive regulation of integrin-mediated signaling pathway GO:2001046 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    basement membrane GO:0005604 IBA
    basement membrane GO:0005604 IDA
    basement membrane GO:0005604 ISO
    basement membrane GO:0005604 ISS
    basement membrane GO:0005604 NAS
    laminin-1 complex GO:0005606 ISO
    neuromuscular junction GO:0031594 IDA
    synaptic cleft GO:0043083 IDA
    laminin-10 complex GO:0043259 IPI
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 ISO
    protein complex involved in cell-matrix adhesion GO:0098637 NAS
 Experiment description of studies that identified Lamc1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lamc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lamc1 226519
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
2 Ntn4  
Reconstituted Complex Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Lama1  
Affinity Capture-Western Mus musculus
5 Tufm  
Cross-Linking-MS (XL-MS) Mus musculus
6 Pou5f1  
Affinity Capture-MS Mus musculus
7 Lamb1 16777
Co-fractionation Mus musculus
8 Hspb2 69253
Affinity Capture-MS Mus musculus
9 Itgb4  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Lamc1 is involved
No pathways found





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