Gene description for IRS2
Gene name	insulin receptor substrate 2
Gene symbol	IRS2
Other names/aliases	IRS-2
Species	Homo sapiens
Database cross references - IRS2
ExoCarta	ExoCarta_8660
Vesiclepedia	VP_8660
Entrez Gene	8660
HGNC	6126
MIM	600797
UniProt	Q9Y4H2
IRS2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Neuroblastoma cells	25944692

Gene ontology annotations for IRS2

Molecular Function     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IEA     insulin receptor binding GO:0005158 IBA     protein binding GO:0005515 IPI     protein phosphatase binding GO:0019903 IEA     protein domain specific binding GO:0019904 IEA     signaling adaptor activity GO:0035591 IDA     phosphatidylinositol 3-kinase binding GO:0043548 IBA     14-3-3 protein binding GO:0071889 IEA     phosphatidylinositol 3-kinase activator activity GO:0141038 IEA Biological Process     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     negative regulation of B cell apoptotic process GO:0002903 ISS     glucose metabolic process GO:0006006 TAS     signal transduction GO:0007165 TAS     brain development GO:0007420 IEA     positive regulation of cell population proliferation GO:0008284 NAS     insulin receptor signaling pathway GO:0008286 IBA     insulin receptor signaling pathway GO:0008286 ISS     response to glucose GO:0009749 ISS     epithelial cell migration GO:0010631 IEA     positive regulation of epithelial cell migration GO:0010634 IEA     negative regulation of long-chain fatty acid import across plasma membrane GO:0010748 IMP     positive regulation of glucose metabolic process GO:0010907 IMP     regulation of lipid metabolic process GO:0019216 TAS     mammary gland development GO:0030879 IEA     positive regulation of B cell proliferation GO:0030890 ISS     positive regulation of fatty acid beta-oxidation GO:0032000 IMP     positive regulation of insulin secretion GO:0032024 ISS     cellular response to insulin stimulus GO:0032869 IMP     negative regulation of kinase activity GO:0033673 ISS     type B pancreatic cell proliferation GO:0044342 IEA     positive regulation of glycogen biosynthetic process GO:0045725 IMP     positive regulation of glycogen biosynthetic process GO:0045725 NAS     positive regulation of D-glucose import GO:0046326 IMP     insulin-like growth factor receptor signaling pathway GO:0048009 IDA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     lipid homeostasis GO:0055088 TAS     cellular response to glucose stimulus GO:0071333 IEA     cellular response to peptide GO:1901653 IEA     positive regulation of type B pancreatic cell proliferation GO:1904692 IEA Subcellular Localization     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 TAS