Gene description for INPP4B
Gene name inositol polyphosphate-4-phosphatase, type II, 105kDa
Gene symbol INPP4B
Other names/aliases -
Species Homo sapiens
 Database cross references - INPP4B
ExoCarta ExoCarta_8821
Vesiclepedia VP_8821
Entrez Gene 8821
HGNC 6075
MIM 607494
UniProt O15327  
 INPP4B identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for INPP4B
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0016316 IBA
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0016316 TAS
    inositol-1,3,4-trisphosphate 4-phosphatase activity GO:0017161 TAS
    inositol-3,4-bisphosphate 4-phosphatase activity GO:0052828 TAS
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    signal transduction GO:0007165 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA
    inositol phosphate metabolic process GO:0043647 TAS
    phosphatidylinositol dephosphorylation GO:0046856 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified INPP4B in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for INPP4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPP3 10072
Co-fractionation Homo sapiens
2 SCIN 85477
Co-fractionation Homo sapiens
3 ZAK 51776
Co-fractionation Homo sapiens
4 MSH2 4436
Co-fractionation Homo sapiens
5 PYCARD 29108
Affinity Capture-MS Homo sapiens
6 PPM1H  
Co-fractionation Homo sapiens
7 UBA1 7317
Co-fractionation Homo sapiens
8 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
9 AP1M1 8907
Co-fractionation Homo sapiens
10 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
11 HNRNPR 10236
Co-fractionation Homo sapiens
12 CAP2 10486
Co-fractionation Homo sapiens
13 MCAM 4162
Proximity Label-MS Homo sapiens
14 SEPT9 10801
Co-fractionation Homo sapiens
15 TRMT61A 115708
Co-fractionation Homo sapiens
16 EEF1E1 9521
Co-fractionation Homo sapiens
17 GORASP2 26003
Co-fractionation Homo sapiens
18 ZNF131  
Affinity Capture-MS Homo sapiens
19 AP1B1 162
Co-fractionation Homo sapiens
20 GBE1 2632
Co-fractionation Homo sapiens
21 DNAJC3 5611
Co-fractionation Homo sapiens
22 AP1G1 164
Co-fractionation Homo sapiens
23 ITPK1 3705
Co-fractionation Homo sapiens
24 SLC31A1 1317
Affinity Capture-MS Homo sapiens
25 AIMP2 7965
Co-fractionation Homo sapiens
26 TRMT6 51605
Co-fractionation Homo sapiens
View the network image/svg+xml



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