Gene description for TMEM11
Gene name transmembrane protein 11
Gene symbol TMEM11
Other names/aliases C17orf35
PM1
PMI
Species Homo sapiens
 Database cross references - TMEM11
ExoCarta ExoCarta_8834
Vesiclepedia VP_8834
Entrez Gene 8834
HGNC 16823
UniProt P17152  
 TMEM11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM11
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitochondrion organization GO:0007005 IMP
    inner mitochondrial membrane organization GO:0007007 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    plasma membrane GO:0005886 NAS
 Experiment description of studies that identified TMEM11 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
3 ST8SIA3  
Affinity Capture-MS Homo sapiens
4 SLC30A8  
Two-hybrid Homo sapiens
5 SLC10A6  
Two-hybrid Homo sapiens
6 ANLN 54443
Affinity Capture-MS Homo sapiens
7 FAM210B  
Two-hybrid Homo sapiens
8 CCR4 1233
Two-hybrid Homo sapiens
9 CD4 920
Affinity Capture-MS Homo sapiens
10 TMEM205 374882
Two-hybrid Homo sapiens
11 BNIP3L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 CD79A  
Two-hybrid Homo sapiens
13 GJB4  
Two-hybrid Homo sapiens
14 DUSP12 11266
Affinity Capture-MS Homo sapiens
15 TMPRSS2 7113
Two-hybrid Homo sapiens
16 NDUFS3 4722
Two-hybrid Homo sapiens
17 COQ9  
Affinity Capture-MS Homo sapiens
18 FAM174A 345757
Two-hybrid Homo sapiens
19 PRC1 9055
Affinity Capture-MS Homo sapiens
20 MUC1 4582
Two-hybrid Homo sapiens
21 SUV39H1  
Two-hybrid Homo sapiens
22 AGTR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CLN8 2055
Two-hybrid Homo sapiens
24 RIC3  
Two-hybrid Homo sapiens
25 LEPROTL1 23484
Two-hybrid Homo sapiens
26 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CD8B 926
Affinity Capture-MS Homo sapiens
28 TMEM106C 79022
Two-hybrid Homo sapiens
29 IMPDH1 3614
Affinity Capture-MS Homo sapiens
30 FATE1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 CLDN7 1366
Two-hybrid Homo sapiens
32 TMEM14B  
Two-hybrid Homo sapiens
33 CX3CL1  
Affinity Capture-MS Homo sapiens
34 TMEM88  
Two-hybrid Homo sapiens
35 PEX12  
Two-hybrid Homo sapiens
36 CYB5D2  
Two-hybrid Homo sapiens
37 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 GORAB 92344
Two-hybrid Homo sapiens
39 NTRK3 4916
Affinity Capture-MS Homo sapiens
40 YWHAE 7531
Affinity Capture-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PDZK1IP1 10158
Two-hybrid Homo sapiens
44 ARL13B 200894
Two-hybrid Homo sapiens
45 TEX29  
Two-hybrid Homo sapiens
46 ACTG1 71
Affinity Capture-MS Homo sapiens
47 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SGCB 6443
Two-hybrid Homo sapiens
49 RNASEH1 246243
Two-hybrid Homo sapiens
50 DUSP22  
Affinity Capture-MS Homo sapiens
51 BCAM 4059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 MRM1  
Two-hybrid Homo sapiens
53 TMIE  
Two-hybrid Homo sapiens
54 FFAR2  
Two-hybrid Homo sapiens
55 YIPF6 286451
Two-hybrid Homo sapiens
56 MTIF3  
Two-hybrid Homo sapiens
57 CMKLR1 1240
Affinity Capture-MS Homo sapiens
58 YWHAZ 7534
Affinity Capture-MS Homo sapiens
59 CCDC155  
Two-hybrid Homo sapiens
60 LRRC32 2615
Affinity Capture-MS Homo sapiens
61 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SUSD3 203328
Two-hybrid Homo sapiens
64 DUSP6 1848
Affinity Capture-MS Homo sapiens
65 CD226 10666
Affinity Capture-MS Homo sapiens
66 FAM209A 200232
Two-hybrid Homo sapiens
67 FAM134C 162427
Two-hybrid Homo sapiens
68 TMEM237 65062
Two-hybrid Homo sapiens
69 DUSP9  
Affinity Capture-MS Homo sapiens
70 DDRGK1 65992
Affinity Capture-MS Homo sapiens
71 BNIP3 664
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
72 SLC22A4 6583
Affinity Capture-MS Homo sapiens
73 PDE3A  
Affinity Capture-MS Homo sapiens
74 CREB3L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 DRD2  
Two-hybrid Homo sapiens
76 TSPAN10 83882
Affinity Capture-MS Homo sapiens
77 SLC2A12 154091
Affinity Capture-MS Homo sapiens
78 TNFSF14  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
79 CCDC70  
Two-hybrid Homo sapiens
80 EBP  
Two-hybrid Homo sapiens
81 TAS1R3  
Affinity Capture-MS Homo sapiens
82 UFL1 23376
Affinity Capture-MS Homo sapiens
83 MOV10 4343
Affinity Capture-RNA Homo sapiens
84 SLC5A8 160728
Affinity Capture-MS Homo sapiens
85 ADORA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 BDKRB2  
Two-hybrid Homo sapiens
87 TMPRSS11A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PLD6  
Affinity Capture-MS Homo sapiens
89 ELOVL4  
Two-hybrid Homo sapiens
90 CXCL16 58191
Affinity Capture-MS Homo sapiens
91 OTX2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM11 is involved
PathwayEvidenceSource
Cristae formation IEA Reactome
Mitochondrial biogenesis IEA Reactome
Organelle biogenesis and maintenance IEA Reactome





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