Gene description for CLDN6
Gene name claudin 6
Gene symbol CLDN6
Other names/aliases -
Species Homo sapiens
 Database cross references - CLDN6
ExoCarta ExoCarta_9074
Vesiclepedia VP_9074
Entrez Gene 9074
HGNC 2048
MIM 615798
UniProt P56747  
 CLDN6 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CLDN6
Molecular Function
    virus receptor activity GO:0001618 IMP
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISS
Biological Process
    cell adhesion GO:0007155 IBA
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 ISS
    symbiont entry into host cell GO:0046718 IEA
    bicellular tight junction assembly GO:0070830 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 ISS
    apicolateral plasma membrane GO:0016327 IEA
 Experiment description of studies that identified CLDN6 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLDN6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MS4A3  
Two-hybrid Homo sapiens
2 PMP22  
Two-hybrid Homo sapiens
3 MUC1 4582
Two-hybrid Homo sapiens
4 TMEM179B 374395
Two-hybrid Homo sapiens
5 TJP1 7082
Reconstituted Complex Homo sapiens
6 IGFBP5 3488
Two-hybrid Homo sapiens
View the network image/svg+xml



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