Gene description for CD1D
Gene name CD1d molecule
Gene symbol CD1D
Other names/aliases CD1A
R3
Species Homo sapiens
 Database cross references - CD1D
ExoCarta ExoCarta_912
Vesiclepedia VP_912
Entrez Gene 912
HGNC 1637
MIM 188410
UniProt P15813  
 CD1D identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CD1D
Molecular Function
    protein binding GO:0005515 IPI
    beta-2-microglobulin binding GO:0030881 TAS
    lipid antigen binding GO:0030882 IDA
    endogenous lipid antigen binding GO:0030883 IBA
    exogenous lipid antigen binding GO:0030884 IBA
    exogenous lipid antigen binding GO:0030884 IDA
    cell adhesion molecule binding GO:0050839 IPI
    lipopeptide binding GO:0071723 IBA
Biological Process
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    immune response GO:0006955 IBA
    detection of bacterium GO:0016045 TAS
    heterotypic cell-cell adhesion GO:0034113 TAS
    positive regulation of T cell proliferation GO:0042102 IDA
    T cell selection GO:0045058 TAS
    innate immune response GO:0045087 IEA
    positive regulation of innate immune response GO:0045089 TAS
    antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 IBA
    antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 IDA
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IDA
    endosome membrane GO:0010008 IEA
    basolateral plasma membrane GO:0016323 IEA
 Experiment description of studies that identified CD1D in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CD1D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM63A 55793
Affinity Capture-MS Homo sapiens
2 CALR 811
Affinity Capture-Western Homo sapiens
3 P4HTM  
Affinity Capture-Western Homo sapiens
4 CANX 821
Affinity Capture-Western Homo sapiens
5 PTPRC 5788
Affinity Capture-Western Homo sapiens
6 B2M 567
Affinity Capture-Western Homo sapiens
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