Gene description for S1PR2
Gene name sphingosine-1-phosphate receptor 2
Gene symbol S1PR2
Other names/aliases AGR16
EDG-5
EDG5
Gpcr13
H218
LPB2
S1P2
Species Homo sapiens
 Database cross references - S1PR2
ExoCarta ExoCarta_9294
Vesiclepedia VP_9294
Entrez Gene 9294
HGNC 3169
MIM 605111
UniProt O95136  
 S1PR2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for S1PR2
Molecular Function
    G protein-coupled receptor binding GO:0001664 IPI
    G protein-coupled receptor activity GO:0004930 TAS
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 TAS
    G protein-coupled peptide receptor activity GO:0008528 IPI
    sphingosine-1-phosphate receptor activity GO:0038036 IBA
    sphingosine-1-phosphate receptor activity GO:0038036 IDA
    sphingosine-1-phosphate receptor activity GO:0038036 IMP
Biological Process
    sphingosine-1-phosphate receptor signaling pathway GO:0003376 IBA
    sphingosine-1-phosphate receptor signaling pathway GO:0003376 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    positive regulation of cell population proliferation GO:0008284 TAS
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 IMP
    regulation of metabolic process GO:0019222 IBA
    actin cytoskeleton organization GO:0030036 IMP
    filopodium assembly GO:0046847 IMP
    excitatory postsynaptic potential GO:0060079 IEA
    negative regulation of excitatory postsynaptic potential GO:0090394 IEA
    regulation of postsynapse assembly GO:0150052 IEA
    positive regulation of establishment of endothelial barrier GO:1903142 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    presynapse GO:0098793 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified S1PR2 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for S1PR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LPAR1 1902
Affinity Capture-MS Homo sapiens
3 TTYH1  
Affinity Capture-MS Homo sapiens
4 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HPCAL1 3241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ARVCF 421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TSPAN15 23555
Affinity Capture-MS Homo sapiens
9 GNAQ 2776
Affinity Capture-MS Homo sapiens
10 MFSD8 256471
Affinity Capture-MS Homo sapiens
11 GAP43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TNFSF18 8995
Affinity Capture-MS Homo sapiens
13 PALM3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ARL5A 26225
Affinity Capture-MS Homo sapiens
15 FKBP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ACP2 53
Affinity Capture-MS Homo sapiens
17 PAG1 55824
Affinity Capture-MS Homo sapiens
18 NDRG1 10397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 POMK  
Affinity Capture-MS Homo sapiens
20 C8G 733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SRC 6714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PTER 9317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ATP5B 506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 REEP6  
Affinity Capture-MS Homo sapiens
25 WDFY1 57590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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