Gene description for SLC22A6
Gene name solute carrier family 22 (organic anion transporter), member 6
Gene symbol SLC22A6
Other names/aliases HOAT1
OAT1
PAHT
ROAT1
Species Homo sapiens
 Database cross references - SLC22A6
ExoCarta ExoCarta_9356
Vesiclepedia VP_9356
Entrez Gene 9356
HGNC 10970
MIM 607582
UniProt Q4U2R8  
 SLC22A6 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A6
Molecular Function
    solute:inorganic anion antiporter activity GO:0005452 IDA
    protein binding GO:0005515 IPI
    organic anion transmembrane transporter activity GO:0008514 IDA
    organic anion transmembrane transporter activity GO:0008514 IMP
    organic anion transmembrane transporter activity GO:0008514 TAS
    prostaglandin transmembrane transporter activity GO:0015132 IDA
    alpha-ketoglutarate transmembrane transporter activity GO:0015139 IDA
    antiporter activity GO:0015297 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IBA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IDA
    transmembrane transporter activity GO:0022857 IDA
    chloride ion binding GO:0031404 IEA
    identical protein binding GO:0042802 IEA
    xenobiotic transmembrane transporter activity GO:0042910 IDA
Biological Process
    monoatomic anion transport GO:0006820 IEA
    response to organic cyclic compound GO:0014070 IEA
    inorganic anion transport GO:0015698 IEA
    organic anion transport GO:0015711 IBA
    organic anion transport GO:0015711 IDA
    organic anion transport GO:0015711 IMP
    prostaglandin transport GO:0015732 IDA
    alpha-ketoglutarate transport GO:0015742 IDA
    xenobiotic transport GO:0042908 IEA
    sodium-independent organic anion transport GO:0043252 IDA
    sodium-independent organic anion transport GO:0043252 IEA
    transmembrane transport GO:0055085 IEA
    metanephric proximal tubule development GO:0072237 IEA
    renal tubular secretion GO:0097254 IMP
    renal tubular secretion GO:0097254 NAS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IEA
    basal plasma membrane GO:0009925 IDA
    basolateral plasma membrane GO:0016323 IDA
    protein-containing complex GO:0032991 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC22A6 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC25A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLC25A24 29957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NEDD4 4734
Affinity Capture-Western Homo sapiens
4 SLC20A2 6575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ATL2 64225
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC26A2 1836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RAB32 10981
Affinity Capture-MS Homo sapiens
9 ITPRIP  
Affinity Capture-MS Homo sapiens
10 LPCAT3 10162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PDXDC1 23042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 IL3RA  
Affinity Capture-MS Homo sapiens
13 APP 351
Reconstituted Complex Homo sapiens
14 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
15 APPBP2  
Two-hybrid Homo sapiens
16 ERGIC2 51290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHPT1  
Affinity Capture-MS Homo sapiens
18 MCU 90550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 YIF1A 10897
Affinity Capture-MS Homo sapiens
20 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 GK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM126B 55863
Affinity Capture-MS Homo sapiens
23 MTX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SLC38A7 55238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SLC25A46 91137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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