Gene description for ATL2
Gene name atlastin GTPase 2
Gene symbol ATL2
Other names/aliases ARL3IP2
ARL6IP2
atlastin2
Species Homo sapiens
 Database cross references - ATL2
ExoCarta ExoCarta_64225
Vesiclepedia VP_64225
Entrez Gene 64225
HGNC 24047
MIM 609368
UniProt Q8NHH9  
 ATL2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for ATL2
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 NAS
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    identical protein binding GO:0042802 IDA
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    endoplasmic reticulum organization GO:0007029 IBA
    endoplasmic reticulum organization GO:0007029 IMP
    Golgi organization GO:0007030 IMP
    protein homooligomerization GO:0051260 IBA
    protein homooligomerization GO:0051260 IDA
    endoplasmic reticulum tubular network membrane organization GO:1990809 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    membrane GO:0016020 HDA
    membrane GO:0016020 IDA
    endoplasmic reticulum tubular network membrane GO:0098826 IDA
 Experiment description of studies that identified ATL2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 TM4SF5  
Affinity Capture-MS Homo sapiens
3 COPG2 26958
Affinity Capture-MS Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ACRBP  
Affinity Capture-MS Homo sapiens
7 IDH1 3417
Affinity Capture-MS Homo sapiens
8 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
9 HCST  
Affinity Capture-MS Homo sapiens
10 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
11 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RPA2 6118
Proximity Label-MS Homo sapiens
13 STK39 27347
Affinity Capture-MS Homo sapiens
14 FPR1  
Affinity Capture-MS Homo sapiens
15 DPEP1 1800
Affinity Capture-MS Homo sapiens
16 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
17 COPA 1314
Affinity Capture-MS Homo sapiens
18 RTN4 57142
Affinity Capture-MS Homo sapiens
19 HCCS 3052
Affinity Capture-MS Homo sapiens
20 RGL1  
Affinity Capture-MS Homo sapiens
21 KIAA1429 25962
Affinity Capture-MS Homo sapiens
22 SLC15A1  
Affinity Capture-MS Homo sapiens
23 BCL7B  
Affinity Capture-MS Homo sapiens
24 COPB2 9276
Affinity Capture-MS Homo sapiens
25 PTCHD3  
Affinity Capture-MS Homo sapiens
26 SYVN1 84447
Affinity Capture-Western Homo sapiens
27 SLC6A5  
Affinity Capture-MS Homo sapiens
28 ADD1 118
Affinity Capture-MS Homo sapiens
29 F2RL1  
Affinity Capture-MS Homo sapiens
30 FAM120A 23196
Affinity Capture-MS Homo sapiens
31 GPR17 2840
Affinity Capture-MS Homo sapiens
32 YWHAB 7529
Affinity Capture-MS Homo sapiens
33 NNT 23530
Affinity Capture-MS Homo sapiens
34 GCGR  
Affinity Capture-MS Homo sapiens
35 KLHDC2  
Affinity Capture-MS Homo sapiens
36 IFITM3 10410
Affinity Capture-MS Homo sapiens
37 COPE 11316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SUPT5H 6829
Affinity Capture-MS Homo sapiens
39 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 COPG1 22820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 IL1R2  
Affinity Capture-MS Homo sapiens
42 ACACA 31
Negative Genetic Homo sapiens
43 ARL6 84100
Two-hybrid Homo sapiens
44 SMARCA4 6597
Affinity Capture-MS Homo sapiens
45 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 GPR182  
Affinity Capture-MS Homo sapiens
48 SNRNP27  
Affinity Capture-MS Homo sapiens
49 REEP5 7905
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 OGT 8473
Reconstituted Complex Homo sapiens
51 SLC22A6 9356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 APLNR  
Affinity Capture-MS Homo sapiens
53 RPN2 6185
Proximity Label-MS Homo sapiens
54 ATL3 25923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CD79B 974
Affinity Capture-MS Homo sapiens
56 CMKLR1 1240
Affinity Capture-MS Homo sapiens
57 BCAP31 10134
Proximity Label-MS Homo sapiens
58 HSD3B7 80270
Proximity Label-MS Homo sapiens
59 YWHAZ 7534
Affinity Capture-MS Homo sapiens
60 LAMA1 284217
Affinity Capture-MS Homo sapiens
61 OPRL1 4987
Affinity Capture-MS Homo sapiens
62 TCIRG1 10312
Affinity Capture-MS Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 ATP2A1 487
Proximity Label-MS Homo sapiens
65 GPR45  
Affinity Capture-MS Homo sapiens
66 CMTM5  
Affinity Capture-MS Homo sapiens
67 LSM11  
Affinity Capture-MS Homo sapiens
68 P2RY10  
Affinity Capture-MS Homo sapiens
69 CACNG1  
Affinity Capture-MS Homo sapiens
70 AVPR2  
Affinity Capture-MS Homo sapiens
71 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 FASN 2194
Negative Genetic Homo sapiens
75 COPZ1 22818
Affinity Capture-MS Homo sapiens
76 DENND1A 57706
Affinity Capture-MS Homo sapiens
77 MFSD4  
Affinity Capture-MS Homo sapiens
78 SLC7A13  
Affinity Capture-MS Homo sapiens
79 NELFA  
Affinity Capture-MS Homo sapiens
80 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 CNGA3  
Affinity Capture-MS Homo sapiens
82 Copa 12847
Affinity Capture-MS Mus musculus
83 RPP38 10557
Affinity Capture-MS Homo sapiens
84 ESYT1 23344
Affinity Capture-MS Homo sapiens
85 FPR2  
Affinity Capture-MS Homo sapiens
86 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATL2 is involved
No pathways found





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