Gene description for CPNE6
Gene name copine VI (neuronal)
Gene symbol CPNE6
Other names/aliases -
Species Homo sapiens
 Database cross references - CPNE6
ExoCarta ExoCarta_9362
Vesiclepedia VP_9362
Entrez Gene 9362
HGNC 2319
MIM 605688
UniProt O95741  
 CPNE6 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CPNE6
Molecular Function
    phosphatidylserine binding GO:0001786 ISS
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
    calcium-dependent phospholipid binding GO:0005544 IBA
Biological Process
    cell differentiation GO:0030154 IEA
    cellular response to calcium ion GO:0071277 IBA
    postsynaptic actin cytoskeleton organization GO:0098974 IEA
    positive regulation of dendrite extension GO:1903861 IDA
Subcellular Localization
    endosome GO:0005768 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 ISS
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    perikaryon GO:0043204 IEA
    clathrin-coated endocytic vesicle GO:0045334 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CPNE6 in sEVs
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CPNE6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIN1 5300
Two-hybrid Homo sapiens
2 AGR2 10551
Two-hybrid Homo sapiens
3 LAMTOR3 8649
Two-hybrid Homo sapiens
4 GRB7 2886
Two-hybrid Homo sapiens
5 ANXA7 310
Two-hybrid Homo sapiens
6 MEOX2  
Two-hybrid Homo sapiens
7 NOTCH3 4854
Reconstituted Complex Homo sapiens
8 TTR 7276
Two-hybrid Homo sapiens
9 SMN1 6606
Two-hybrid Homo sapiens
10 TK1 7083
Two-hybrid Homo sapiens
11 CDKN1A  
Two-hybrid Homo sapiens
12 MCM2 4171
Affinity Capture-MS Homo sapiens
13 CPNE4 131034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 AK5 26289
Two-hybrid Homo sapiens
15 MAPK11  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CPNE6 is involved
PathwayEvidenceSource
Glycerophospholipid biosynthesis TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Phospholipid metabolism TAS Reactome





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